Clinical trial · Interventional
Effect of Intrathecal Morphine on Quality of Recovery After Laparoscopic Colorectal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer is the second most common tumor in women and the third most common tumor in men, accounting for approximately 10% of tumors diagnosed and tumor-related deaths worldwide each year. Laparoscopic resection has become the standard of colorectal cancer surgery, and its main advantages are to shorten the length of hospital stay, reduce postoperative pain, and accelerate patient recovery. However, it has been reported that about 49% of patients undergoing laparoscopic colorectal cancer surgery still have moderate to severe postoperative pain. The insertion of abdominal drainage tube will increase the degree of postoperative pain, especially when patients take deep breaths, exercise or cough, which will increase the demand for postoperative opioids and reduce the quality of postoperative recovery. How to further reduce the postoperative pain of patients, reduce the dosage of opioids, shorten the length of hospital stay, promote the rapid recovery of patients and improve patient satisfaction are our concerns. Intrathecal morphine can provide a good analgesic effect on visceral pain. At present, intrathecal morphine has become a new method of postoperative analgesia, which is used in thoracic, abdominal and obstetrics and gynecology operations. The objective of this study was to investigate the effect of intrathecal morphine on the quality of recovery after laparoscopic colon cancer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Laparoscopic Colorectal Cancer Surgery | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intrathecal morphine | Procedure | — | UNRESOLVED |
| Intrathecal saline injection | Procedure | — | UNRESOLVED |
| TAPB | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intrathecal morphine group
- description
- Before induction of anesthesia, the experimental group received intrathecal morphine in the lumbar segment (L3/4).For our preliminary clinical application, the intrathecal morphine was 3ug/kg
- interventionNames
- Procedure: Intrathecal morphine
- Procedure: TAPB
- type
- ACTIVE_COMPARATOR
- label
- Normal saline group
- description
- Before anesthesia induction, the control group received intrathecal injection of normal saline.
- interventionNames
- Procedure: Intrathecal saline injection
- Procedure: TAPB
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Laparoscopic colorectal cancer surgery under tracheal intubation and general anesthesia is intended * Agreed to use intravaginal morphine injection and bupivacaine liposomal plane block of transversal muscle after surgery * ASA Grade I - III * Over 18 years of age Exclusion Criteria: * Preoperative accident or subjective refusal of surgery * Nervous system dysfunction * Contraindications to intraspinal anesthesia * Preoperative opioid use history * Patients with abnormal preoperative pain and pain score (NRS) \>3
References
Publications (1)
- DERIVEDZheng L, Lu Y, Lu X, You L, Yu C, Lai J, Xu M, Xie M, Xiao Y, Lai R. Intrathecal Morphine for Enhanced Recovery After Laparoscopic Colorectal Surgery: A Randomized Clinical Trial. JAMA Surg. 2026 Feb 1;161(2):124-131. doi: 10.1001/jamasurg.2025.5699. PMID 41433024