Clinical trial · Observational
Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements
NCT06630338CI-TRIAL-00106594not yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 17, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260917-000001
Summary
Brief summary (as posted)
This study investigates the role of intraoperative shear wave elastography ultrasound (ISWEU) in identifying healthy brain and tumor tissue stiffness differences. This data may be used to guide tumor resection in future patients.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasm | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Recurrent Brain Neoplasm | Brain Neoplasm | CURATED_BROADER | 0.78 |
| Recurrent Brain Tumor | Brain Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-Interventional Study | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Observational
- description
- Patients undergo shear wave elastography ultrasound over 10-15 minutes during their standard of care surgery on study.
- interventionNames
- Other: Non-Interventional Study
Primary outcomes (1)
- measure
- Feasibility of utilizing Intraoperative Shear Wave Elastography Ultrasound (ISWEU) measurements intraoperatively and in the human brain to measure tissue stiffness.
- timeFrame
- At baseline
- description
- After intraoperative measurement of brain stiffness using ISWEU, analysis will be conducted after each procedure by determining the tissue stiffness from different areas (tumor core, peritumoral brain zone, and non-cancerous brain tissue) and comparing the tumor stiffness between patients. Reviewers will determine whether ISWEU is feasible to be used as a tool to influence surgical decision.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients must be at least 18 years old. * Patients must have planned surgery for resection of a newly diagnosed or recurrent brain tumors. * Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications. * Patients must have a Karnofsky performance status ≥ 60%. * Patient or legally authorized representative (LAR) willing to provide written informed consent. Exclusion Criteria: * Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk. * Patients with a history of any brain infections. * Patients with implanted devices. * Patients with any other neurological/neurosurgical disease that could affect tissue stiffness. * Patients with any other structural brain defect that could affect tissue stiffness.
References
Publications (0)
Data not yet available
No reference posted for this study.