Clinical trial · Observational
Ten-Year Outcomes of Operable Solitary Hepatocellular Carcinoma Patients: Impact of Tumor Size Over 6.5 cm and Microvascular Invasion
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to evaualte the impact of tumor size and microvascular invasion among patients with solitary hepatocellualr carcinoma and post operation. The main questions it aims to answer are: Does the tumor size have more impact on the survival and recurrence than microvascular invasion among solitary operable hepatocellular carcinoma patients? Researchers will retrospectively analyze the prospectively collected clinical database during January 2022 and December 2019 to see whether tumor size more than 6.5 cm or microvascular invasion. The solitary operable hepatocellular carcinoma patients would be classified based on the status of microvascular invasion and tumor size, and the outcome would be evaluated among different sub-populations of the feasible subjects.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma (HCC) | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.85 |
| Solitary Mass | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgery for HCC larger than 2 cm | Procedure | — | UNRESOLVED |
| Surgery for HCC larger than 6.5 cm | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Solitary HCC larger than 6.5 cm without mVI
- description
- Operable solitary HCC larger than 6.5 cm without mVI
- interventionNames
- Procedure: Surgery for HCC larger than 6.5 cm
- label
- Solitary HCC larger than 2 cm with mVI
- description
- Operable solitary HCC larger than 2 cm with mVI
- interventionNames
- Procedure: Surgery for HCC larger than 2 cm
Primary outcomes (1)
- measure
- 10-year overall survival
- timeFrame
- From enrollment to the end date of 10 years or the mortality occurs.
- description
- 10-year overall survival of different cohorts
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Operable solitary hepatocellular carcinoma Exclusion Criteria: * Not pT1N0M0 or pT2N0M0 * Missing tumor size * Errors in survival/recurrence dates or status
References
Publications (2)
- RESULTLee CW, Yu MC, Wang CC, Lee WC, Tsai HI, Kuan FC, Chen CW, Hsieh YC, Chen HY. Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study. World J Gastrointest Surg. 2021 May 27;13(5):476-492. doi: 10.4240/wjgs.v13.i5.476. PMID 34122737
- RESULTLee CW, Tsai HI, Yu MC, Wang CC, Lee WC, Yeh TS, Yeh CN, Lin CY, Kuo T, Chen HY. A proposal for T1 subclassification in hepatocellular carcinoma: reappraisal of the AJCC 8th edition. Hepatol Int. 2022 Dec;16(6):1353-1367. doi: 10.1007/s12072-022-10422-8. Epub 2022 Sep 28. PMID 36169915