Clinical trial · Interventional
Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells
Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells A Prospective, Single-center, Pilot, Randomized Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to learn if sevoflurane-based inhalational anesthesia (s-IA) and propofol-based total intravenous anesthesia (p-TVA) have different effects on HSP70 expression in different types of tumour cells. The main questions it aims to answer are: * if p-TVA/s-IA increase or suppress HSP70 expression in tumor cells in comparison with a pre-anesthesia level; * does this change in HSP70 expression cause any difference in vital characteristics of tumor cells, such as proliferation, apoptosis, colony formation and migration. Researchers will compare p-TVA with s-IA by ability of these types of anesthesia to change the HSP70 expression level and modulate HSP70-mediated effects in tumor cells. Participants will: * be randomly allocated to p-TVA or s-IA groups; * donate 12 ml of blood before anesthesia induction and 12 ml after 2 hours of anesthesia. The blood serum will be used to prepare cell medium. After exposure to this medium, cells from different tumor types will be investigated using cytological and molecular biological methods.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cancer Recurrence | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Propofol-based total venous anesthesia group
- description
- These patients will receive total venous anethesia where propofol is used as a hypnotic drug.
- interventionNames
- Drug: Propofol
- type
- EXPERIMENTAL
- label
- Sevoflurane-based inhalational anesthesia group
- description
- These patients will receive inhalational anethesia where sevoflurane is used as a hypnotic drug.
- interventionNames
- Drug: Sevoflurane
Primary outcomes (1)
- measure
- HSP70 expression in tumor cells in vitro
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed malignant neoplasm * Planned surgery for radical or palliative tumor resection * Age over 18 years * Signed informed consent Exclusion Criteria: * Diabetes mellitus type 2 * HIV, hepatitis B or C * Emergency surgery * Known or suspected allergy to studied drugs * Other conditions when one of the types of anesthesia is more preferable (hemodynamic disorders, bronchial asthma etc)
References
Publications (0)
Data not yet available