Clinical trial · Observational
Strain-elastography in Endometrial Cancer
Can Elastographic Evaluation Be a New Approach in Prediction of Endometrial Cancer Prognostic Markers?
NCT06623916CI-TRIAL-00081235completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Strain elastography is a novel, non-invasive, easy applicable method to determine the tissue characteristics of benign or malign lesions in various organs. In this preliminary prospective study, we investigated the relation between the known pathological prognostic factors of endometrial cancer and elastographic characteristics of tumor tissue
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endometrial Cancer Survivors | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- feasibility; to compare the stiffness and strain character of tumor tissue with well-known pathological prognostic factors of endometrial cancer.
- timeFrame
- strain ratio measurements of tumor tissue were performed one night before the operation. these data were compared with pathological reports which results 1 month after the cytoreductive surgery.
- description
- The strain measurements are displayed as a semitransparent color map called an elastogram, which is overlaid on the b-mode image. Typically, low strain (stiff tissue) is displayed in blue, and high strain (soft tissue) is displayed in red, although the color scale can vary depending on the ultrasound vendor. A pseudo-quantitative measurement called the strain ratio can be used, which is the ratio of strain measured in adjacent (usually normal) reference tissue region of interest (ROI) to strain measured in a target lesion ROI. SR \>1 indicates that the target lesion compresses less than the normal reference tissue, indicating lower strain and greater stiffness.The receiver operating characteristics (ROC) analysis was used to determine whether the mean strain ratio values had a statistically significant effect on the differentiation in well known pathological prognostic factors.
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Patients with epitheliel endometrial cancer diagnosis with biopsy. Exclusion Criteria: * Diagnosis of different types of tumors in the last 5 years * Presence of synchronous malignancy, presence of non epithelial uterine tumor * Lack of patient data * Presence of full-thickness uterine and cervical involvement (lack of evaluation for elastography) * Lack of patient compliance for transvaginal ultrasound * Inoperable cases (lack of definitive pathologic report)
References
Publications (1)
- BACKGROUNDOng CL, Chew LE, Han NR, Ooi CC, Yeo YC, Chew SH, Wong WL, Tang PH, Teo SY. The Characteristics of Real-time Transvaginal Sono-elastography in Endometrial Cancer. J Med Ultrasound. 2022 Jan 6;30(2):101-108. doi: 10.4103/JMU.JMU_74_21. eCollection 2022 Apr-Jun. PMID 35832355