Clinical trial · Observational
Clinico-immunological Characterization and Immune Tolerance Breakdown in CV2-autoimmunity
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Paraneoplastic neurological syndromes are rare syndromes caused by the remote effects of cancer. They have an immune-mediated pathogenesis, yet the underlying mechanisms are not fully elucidated. CV2/Collapsin response-mediator protein 5 (CRMP5)-IgG paraneoplastic neurological syndrome is characterized by heterogeneous clinical presentations, affecting both central and peripheral nervous system, and the most frequently associate tumor is small cell lung carcinoma. Central nervous system involvement along with CSF and neuroimaging findings have not been fully described in the literature in CV2/CRMP5 patients. Unraveling the complexities of CV2/CRMP5 paraneoplastic neurological syndrome is critical to improve diagnosis, treatment, and patients' care. Our intention is to perform a comprehensive analysis of the clinical characteristics and instrumental investigations of a large cohort of CV2/CRMP5 patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CV2 Autoimmunity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Description of clinical, immunological and tumor features of patients harboring CV2 Abs | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients with CV2 Abs
- description
- Patients harboring CV2 Abs and a paraneoplastic neurological syndromes.
- interventionNames
- Other: Description of clinical, immunological and tumor features of patients harboring CV2 Abs
Primary outcomes (1)
- measure
- Modified Rankin Scale (mRs)
- timeFrame
- At baseline, 3, 6, 12, 18 month
- description
- Application of modified rankin scale
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with paraneoplastic neurological syndromes * Patient with CV2 antibody in sera and/or CSF Exclusion Criteria: * Patient with no data * Patient without neurological disorder * Patient without CV2 antibody in sera/CSF
References
Publications (0)
Data not yet available