Clinical trial · Observational
Stereotactic Radiotherapy for Sinonasal Malignancy
Treatment Outcomes and Dosimetric Analysis Comparison Between CyberKnife and VMAT Based Methods of Stereotactic Radiotherapy for Sinonasal Malignancy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Sinonasal Tumors are a rare type of head and neck tumor, accounting for approximately 3% of head and neck cancers. Treatment primarily involves surgical intervention, with radiation therapy as an adjunct. Due to the tumor\'s anatomical location near critical structures such as the eyes, optic nerves, optic chiasm, brainstem, and oral cavity, if the tumor cannot be completely resected, postoperative radiation therapy is often necessary. Given the complexity of the tumor\'s anatomical position, subsequent radiation therapy planning becomes more challenging, as it must balance tumor control and organ preservation. This study retrospectively analyzes patients with sinonasal tumors who received stereotactic radiosurgery (CyberKnife) at our hospital, comparing the dosimetric advantages, treatment efficacy, survival analysis, and side effects with those of volumetric modulated arc therapy (VMAT).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SBRT by Cyberknife | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Sinonasal malignancy patients received post-operative cyberknife
- description
- Sinonasal malignancy patients in our hospital receive curative surgery. These patients received post-operative radiotheray of SBRT by cyberknife.
- interventionNames
- Radiation: SBRT by Cyberknife
Primary outcomes (4)
- measure
- Overall Survival, OS
- timeFrame
- Data within five years after treatment.
- description
- Determine the start dates of surgery and radiotherapy from the hospital\'s medical record system, and collect data on death events, regardless of whether they are tumor-related.
- measure
- Disease-Free Survival, DFS
- timeFrame
- Data within five years after treatment
- description
- Determine the treatment start date from the hospital\'s medical record system, and confirm whether there is any disease recurrence or progression through follow-up data or imaging examination results.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * The pathological tissue report from the endoscopic surgery at this hospital confirmed a diagnosis of malignant sinus tumor. * Received radical stereotactic radiotherapy at this hospital. * Pre-treatment baseline imaging (CT or MRI) was performed. * Received radical radiotherapy at this hospital and has been under long-term follow-up with complete medical records at this hospital. Exclusion Criteria: * Local lymphatic metastasis and distant metastasis have been excluded by imaging examinations (cN \>=1, M =1). * Not treated with radical radiotherapy at this hospital and has been under long-term follow-up at this hospital with incomplete medical records.
References
Publications (0)
Data not yet available