Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer

Inclusion Criteria:

* 1.Age: 18 to 80 years old, male or female;
* 2.Patients with histologically or cytologically confirmed dMMR/MSI-H rectal adenocarcinoma, clinical stage II-III;
* 3.No prior systemic therapy, including chemotherapy, radiotherapy, immunotherapy, or targeted therapy;
* 4.ECOG Performance Status (PS) score of 0-1;
* 5.Estimated life expectancy of ≥ 3 months;
* 6.Normal function of major organs, with no severe abnormalities in blood, heart, lung, liver, kidney, bone marrow, or immunodeficiency. Laboratory tests must meet the following criteria: Hemoglobin (Hb) ≥ 90 g/L; White blood cell count (WBC) ≥ 3.0 × 10\^9/L; Neutrophil count (NEUT) ≥ 1.5 × 10\^9/L; Platelet count (PLT) ≥ 90 × 10\^9/L; Liver function (Aspartate Aminotransferase AST or Alanine Aminotransferase ALT) ≤ 2.5 times the upper limit of normal (ULN); Renal function (serum creatinine sCr) ≤ 1.5 times ULN; Total bilirubin (TBIL) ≤ 1.5 times ULN; Urine protein and occult blood \< 2+; Fecal occult blood \< 2+;
* 7.Subjects must voluntarily participate in this study, sign the informed consent form, demonstrate good compliance, and cooperate with follow-up visits;
* 8.The investigator believes that the patient can benefit from the treatment. Physical status score PS ≤ 2;
* 9.Patients and their families must understand and be willing to participate in this study, providing written informed consent.

Exclusion Criteria:

* 1.Patients with a confirmed allergy to the investigational drug and/or its excipients;
* 2.Subjects who have received or are currently receiving additional chemotherapy, radiotherapy, targeted therapy, or immunotherapy;
* 3.Patients with any active autoimmune disease or a history of autoimmune disease;
* 4.Patients with Lynch syndrome;
* 5.Patients with poorly controlled cardiac symptoms or diseases, such as New York Heart Association (NYHA) Class II or higher heart failure, unstable angina pectoris, or myocardial infarction within the past year;
* 6.Pregnant or lactating women;
* 7.Patients with acute infections requiring antibiotic treatment;
* 8.Patients with positive hepatitis B or hepatitis C antibodies;
* 9.Patients with positive HIV antibodies;
* 10.Patients with other diseases that the investigating physician considers may affect prognosis and survival;
* 11.Any other conditions deemed inappropriate for participation in this study by the investigating physician.