Clinical trial · Interventional
Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis
Ultrasound-guided Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis: a Randomised Clinical Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Enlargement of any bursa in or around the popliteal fossa (most commonly the gastrocnemio-semimembranosus (GS) bursa) is called a Baker cyst (BC). Common clinical manifestations of BCs are swelling, mass, pain or stiffness, usually worsening with activity. There may be swelling and tightness or pain behind the knee when walking. However, the majority of these cysts are asymptomatic. They can be detected incidentally in the general population but are more commonly found in patients with osteoarthritis of the knee. In previous studies, aspiration or corticosteroid treatment was frequently used to treat baker's cysts in patients with osteoarthritis and meniscal or ligamentous injuries. However, there is no previous study in the literature showing the efficacy of PRP injection in baker's cyst. In our study, we aimed to compare the efficacy of cyst aspiration and PRP injection into the cyst on pain, function and cyst size compared to cyst aspiration.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Baker Cyst | — | UNRESOLVED | — |
| Knee Osteoarthritis | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Platelet Rich Plasma | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Aspiration group
- description
- The existing Baker's cyst of patients in this group will be aspirated under ultrasonographic guidance.
- type
- EXPERIMENTAL
- label
- PRP+Aspiration group
- description
- The existing Baker's cyst of patients in this group will be aspirated under ultrasonography guidance and PRP injection will be administered into the cyst.
- interventionNames
- Other: Platelet Rich Plasma
Primary outcomes (1)
- measure
- Change from enrollment in the numeric rating scale for pain
- timeFrame
- (1) From enrollment to the end of treatment at 6 weeks, (2) From enrollment to the end of treatment at 12 weeks
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of grade 1-2-3 knee osteoarthritis according to Kellgren Lawrence classification * Presence of a baker cyst (popliteal cyst) with at least one of the width or length measurements \>1 cm (proven by magnetic resonans imaging or muskuloskeletal ultrasound examination) Exclusion Criteria: * Patients with grade 4 knee osteoarthritis according to the Kellgren Lawrence classification * Presence of secondary causes other than gonarthrosis which may lead to the development of a Baker cyst, such as meniscopathy, rheumatic diseases or anterior cruciate ligament damage, etc. * Long-term use (more than 3 months) of corticosteroid-containing medication * History of hyaluronic acid injection into the knee within the last 6 months or corticosteroid injection within the last 3 months * Skin lesions in and around the knee area in the last 7 days * Current Hb value \<12 or platelet value \<150,000 * Immunologic or connective tissue disease * Patients with lateral knee joint space narrowing more than medial * History of previous knee surgery * History of pregnancy or breastfeeding
References
Publications (9)
- BACKGROUNDRaeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, Azma K. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015 Jan 7;8:1-8. doi: 10.4137/CMAMD.S17894. eCollection 2015. PMID 25624776
- BACKGROUNDDeasy BM, Feduska JM, Payne TR, Li Y, Ambrosio F, Huard J. Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle. Mol Ther. 2009 Oct;17(10):1788-98. doi: 10.1038/mt.2009.136. Epub 2009 Jul 14. PMID 19603004
- BACKGROUNDBraun HJ, Wasterlain AS, Dragoo JL. The use of PRP in ligament and meniscal healing. Sports Med Arthrosc Rev. 2013 Dec;21(4):206-12. doi: 10.1097/JSA.0000000000000005. PMID 24212368
- BACKGROUNDZhao L, Kaye AD, Abd-Elsayed A. Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review. Pain Physician. 2018 May;21(3):229-242. PMID 29871367
- BACKGROUNDXie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014 Feb 25;16(1):204. doi: 10.1186/ar4493. PMID 25164150
- BACKGROUNDRauschning W. Popliteal cysts (Baker's cysts) in adults. II. Capsuloplasty with and without a pedicle graft. Acta Orthop Scand. 1980 Jun;51(3):547-55. doi: 10.3109/17453678008990839. PMID 7004054
- BACKGROUNDJohnson LL, van Dyk GE, Johnson CA, Bays BM, Gully SM. The popliteal bursa (Baker's cyst): an arthroscopic perspective and the epidemiology. Arthroscopy. 1997 Feb;13(1):66-72. doi: 10.1016/s0749-8063(97)90211-5. PMID 9043606
- BACKGROUNDSansone V, De Ponti A. Arthroscopic treatment of popliteal cyst and associated intra-articular knee disorders in adults. Arthroscopy. 1999 May;15(4):368-72. doi: 10.1016/s0749-8063(99)70053-8.