Clinical trial · Observational
Understanding the Transition from Normal Melanocytes to Nevus to Melanoma
Understanding the Transition from Normal Melanocytes to Nevus to Melanoma (NevustoMel)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Congenital Melanocytic Nevi | Congenital Cutaneous Nevus | ALIAS | 0.90 |
| Melanoma, Skin | Cutaneous Melanoma | ALIAS | 0.90 |
| Nevi and Melanomas | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Liquid biopsy | Genetic | — | UNRESOLVED |
| Methylomics | Genetic | — | UNRESOLVED |
| RNA sequencing | Genetic | — | UNRESOLVED |
| Spatial transcriptomics | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- L/GCMN
- description
- Patients with congenital nevus with estimated size of 20 cm or more in adulthood (\> 18 years old)
- interventionNames
- Genetic: Methylomics
- Genetic: RNA sequencing
- Genetic: Spatial transcriptomics
- Genetic: Liquid biopsy
- label
- Melanoma
- description
- Patients affected with Spitz-type or conventional melanomas in patients under 30 years of age
- interventionNames
- Genetic: Methylomics
- Genetic: RNA sequencing
- Genetic: Spatial transcriptomics
- Genetic: Liquid biopsy
Primary outcomes (1)
- measure
- Molecular identity profiles
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion criteria: * Congenital nevus with estimated size of 20 cm * Be over 18 years of age Exclusion criteria: * No available biological material * Not having signed the informed consent
References
Publications (0)
Data not yet available