Clinical trial · Interventional
Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate
Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate. The traditional method of dye spraying with spraying catheter or syringe would consume a lot of time and dye volume. Now, the more convenient auxiliary water supply channel can be used to spray indigo carmine. In order to explore the clinical application value of spraying indigo carmine solution by auxiliary water channel in high-risk population, we performed a prospective, randomized controlled trial to compare adenoma detection rate of conventional colonoscopy and chromoendoscopy.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenoma Detection Rate | — | UNRESOLVED | — |
| Adenomatous Polyps | Adenomatous Polyp | ALIAS | 0.90 |
| Chromoendoscopy | — | UNRESOLVED | — |
| Colonic Polyps | — | UNRESOLVED | — |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chromoendoscopy | Procedure | — | UNRESOLVED |
| Conventional colonoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Chromoendoscopy with indigo carmine solution spray
- description
- Patients in this group will be carefully observed with spraying indigo carmine solution during the colonoscopy withdraw.
- interventionNames
- Procedure: Chromoendoscopy
- type
- ACTIVE_COMPARATOR
- label
- Conventional colonoscopy without indigo carmine solution spray
- description
- Patients in this group will be carefully observed without spraying anything during the colonoscopy withdraw.
- interventionNames
- Procedure: Conventional colonoscopy
Primary outcomes (1)
- measure
- adenoma detection rate(ADR)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with a history of colorectal cancer or colorectal adenoma * Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma * Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss; * Patients with positive fecal occult blood tests Exclusion Criteria: * Patients with severe comorbidity * Patients who are not suitable for colonoscopy * Patients who received urgent or therapeutic colonoscopy * Patients with pregnancy, inflammatory bowel disease, polyposis syndromes, suspected CRC; intestinal obstruction, coagulopathy * Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days * Patients with failed cecal intubation * Patients with inadequate bowel preparation quality (Boston score ≤5) * Patients who refuse to participate or to provide informed consent
References
Publications (1)
- DERIVEDTian H, Cui C, Wang Q, Zhang R, Sun Y, Zhang M, Ji R. The Efficacy of Pan-Indigo Carmine Chromoendoscopy by Water-Jet Pump in the Detection of Colorectal Lesions: A Randomized Controlled Trial. J Gastroenterol Hepatol. 2026 Aug;41(8):2329-2337. doi: 10.1111/jgh.70504. Epub 2026 Jun 23. PMID 42333873