Clinical trial · Interventional
Oral Cryotherapy Applied to Patients Undergoing Chemotherapy
Examining the Effect of Oral Cryotherapy Applied to Patients Undergoing Chemotherapy on Taste Change, Appetite Level, Malnutrition Risk and Quality of Life
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Taste alteration can cause problems such as loss of appetite, inadequate energy intake and weight loss in oncology patients, increasing the risk of malnutrition and negatively affecting the quality of life of patients. It is thought that other problems mentioned can be prevented and quality of life can be improved with effective management of taste alteration. This study was planned as a randomized controlled, pre-test-post-test and experimental design to determine the effect of oral cryotherapy application on chemotherapy-induced taste alteration, thus on appetite level, malnutrition risk and quality of life.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Chemotherapy | — | UNRESOLVED | — |
| Oncologic Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ICE | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention arm
- description
- Patients in this arm will receive oral cryotherapy.The patients in the intervention group will have ice applied to their mouths for three cycles (the first cycle they met with the researcher and the second and third cycles/an average of two months) when they come for treatment at the hospital with the researcher and at home on the days they do not come for treatment, within the scope of the oral cryotherapy application protocol, they will be monitored by phone and a reminder message will be sent. During chemotherapy, ice cubes will be applied to the patients in the first hour they start receiving chemotherapy and in the same time period, three consecutive ice cubes (each ice cube melts for an average of 1.5-2 minutes/total average of 4.5-6 minutes) and the same application will be repeated three hours later. The patients will be asked to apply ice cubes at home six times (an average of 27-36 minutes/day) at two or three hour intervals for seven days, including the day they receive che
- interventionNames
- Other: ICE
- type
- NO_INTERVENTION
- label
- Control arm
- description
- Patients who meet the study criteria and are included in the control group will receive routine treatment and care procedures in the unit when they come to receive chemotherapy (the first cycle encountered by the researcher) and the other two cycles that follow, and will not receive oral cryotherapy.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Those receiving treatment in an outpatient chemotherapy unit, * Able to communicate verbally, * Literate, * Eastern Cooperative Oncology Group (ECOG) Performance Score of two or below, * Knowing their diagnosis, * Taking five chemotherapeutic agents that cause taste changes, either alone or in combination (cisplatin, docetaxel, paclitaxel, oxaliplatin, vincristine), * Verbally stating that they experience taste changes, * Not smoking or quitting alcohol, * Not using statins, hypothyroidism, antidiabetic, antipsychotic, hyperthyroidism, antidepressant, antihistamine, anti-inflammatory, antibiotic and antifungal drugs, * Not having Chronic Renal Failure (CKD), metabolic (diabetes, thyroid disease, etc.) and liver (hepatitis, cirrhosis) diseases, * Individuals who volunteered to participate in the study were included in the study. Exclusion Criteria: * Patients who have had their treatment postponed at least twice in a row, * Those with a World Health Organization Oral Toxicity Scale score of 1 and above, * Those who have received radiotherapy to the head and neck region, * Those with head/neck, stomach and liver cancer, * Those who cannot be reached during phone calls, * Those whose chemotherapy protocol has changed or who will be applied to a protocol other than the specified agents, * Those with neutropenia (neutrophils; 1000 mcL and below), * Those with tooth sensitivity, * Those who have experienced a change in taste before starting the chemotherapy protocol\*\* and * Those who do not want to continue the study will be excluded from the study.
References
Publications (0)
Data not yet available