Multi-mode Ablation and Molecular Imaging Multi-omics Study for Digestive-Origin Malignant Liver Tumors

Inclusion Criteria:

1. Age 18 and 75 years, gender not specified;
2. Pathologically confirmed primary liver cancer or colorectal cancer liver metastases, which is unresectable, intolerant to surgical resection, or refused surgical resection;
3. Intrahepatic lesions with a diameter of ≤4cm, and the number of lesions ≤3.;
4. At least 3 months since the last systemic treatment and at least 1 month since the last local treatment;
5. Child-Pugh class A or B;
6. ECOG PS ≤ 2.

Exclusion Criteria:

1. Liver function Child-Pugh class C , severe jaundice, especially obstructive jaundice;
2. Diffuse liver cancer, or with tumor thrombi in the main portal vein to secondary branches or hepatic vein;
3. Significant liver atrophy, tumor volume too large, requiring ablation range of up to one-third of the liver volume;
4. Multiple systemic metastases, expected survival \< 3 months;
5. Recent history of esophageal (gastric fundus) variceal bleeding within the past month;
6. Severe functional failure of major organs such as the liver, kidneys, heart, lungs or brain;
7. Presence of active infection;
8. Uncorrectable coagulation dysfunction and severe hematological abnormalities, with a significant bleeding tendency;
9. Refractory massive ascites, pleural effusion, or cachexia;
10. Pregnancy, disorder or inability to cooperate with treatment;
11. Any other factors deemed inappropriate for inclusion or affecting the subject's participation in the study, as determined by the investigators.