Clinical trial · Observational
Investigating How Childhood Tumours and Congenital Disease Develop
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Every cell and every organ in the human body derives from a fertilised egg. As the fertilised egg divides, a human being develops and grows. The process of how the fertilised egg divides and forms a human being is very sophisticated and is directed by the genetic information, the DNA, that is present in every cell. When errors, mutations, in the DNA code arise, the orderly process of human development can be disrupted. This can lead to the development of tumours during childhood and congenital diseases (that is, abnormalities that children are born with). The aim of this study is to define exactly which DNA errors underpin childhood tumours and congenital diseases.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Tumor | Childhood Neoplasm | ALIAS | 0.90 |
| Congenital Disorders | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| sample collection | Other | — | UNRESOLVED |
| Seeking consent and assent | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Research participant with tumour or congenital condition
- description
- The participant identified to have a tumour or congenital condition (a condition from birth) that is likely to be due to errors of the genetic code (DNA).
- interventionNames
- Other: sample collection
- Other: Seeking consent and assent
- label
- Relatives
- description
- parents, siblings or close relatives of the participant with the tumour or congenital condition.
- interventionNames
- Other: sample collection
- Other: Seeking consent and assent
Primary outcomes (1)
- measure
- Description of the genetic mutations of each tumour and congenital anomaly.
- timeFrame
- 9.5 years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Presence of childhood tumour / congenital disease, or relative of participant with childhood tumour / congenital disease * Sufficient \'surplus to diagnostic/clinical use\' tissue is available * Child assent and parental/guardian consent obtained where applicable Exclusion Criteria: * Insufficient surplus tissue is available
References
Publications (0)
Data not yet available