Clinical trial · Interventional
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Rectus Sheath Block With Liposomal Bupivacaine for Postoperative Analgesia Following Gynecologic Oncology Surgery: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml bupivacaine 0.25% per side. Cases will be matched in a 1:2 ratio by age, race, insurance status and duration of surgery with historical controls who received postoperative analgesia using thoracic epidural analgesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gynecologic Surgical Procedures | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bupivacaine Hydrochloride | Drug | — | UNRESOLVED |
| Bupivacaine-Hydromorphone Cassette | Drug | — | UNRESOLVED |
| Liposomal bupivacaine | Drug | — | UNRESOLVED |
| Rectus sheath block | Procedure | — | UNRESOLVED |
| Thoracic Epidural Analgesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Rectus Sheath Block Group (Prospective arm)
- description
- Thirty subjects will be prospectively enrolled and will receive a bilateral rectus sheath block under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml bupivacaine 0.25% per side.
- interventionNames
- Procedure: Rectus sheath block
- Drug: Liposomal bupivacaine
- Drug: Bupivacaine Hydrochloride
- type
- ACTIVE_COMPARATOR
- label
- Thoracic Epidural Analgesia Group (retrospective arm)
- description
- 60 patients who received thoracic epidural analgesia as part of our enhanced recovery after surgery protocol and stayed in hospital for at least 72 h.
- interventionNames
- Procedure: Thoracic Epidural Analgesia
- Drug: Bupivacaine-Hydromorphone Cassette
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients ≥18 years presenting for a laparotomy for Gynecologic malignancy with a vertical incision. 2. ASA Classification II or III. 3. English speaking patients Exclusion Criteria: 1. BMI \>50 kg/m2. 2. Chronic pain or chronic opioid therapy. 3. Allergy or contraindication to local anesthetics or any component of the multimodal analgesic regimen (NSAIDs and acetaminophen)
References
Publications (0)
Data not yet available