Clinical trial · Observational
An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are: * To describe characteristics such as demographics, co-morbidities and environmental exposures * To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible * To describe participant outcomes such as cancer stage, treatment and mortality * To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data. Participants will currently have no change to their usual care.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Demographics, comorbidities and environmental exposures of participants
- timeFrame
- Comorbidities and environmental exposures at diagnosis (approximately up to 156 weeks prior to diagnosis)
- description
- From review of electronic health records
- measure
- Participant pathways including presentation mode and symptoms
- timeFrame
- Presentation mode and symptoms at time of diagnosis (approximately up to 52 weeks prior to diagnosis)
- description
- From review of electronic health records
Secondary outcomes (2)
- measure
- Participant outcomes such as cancer stage, treatment, mortality
- timeFrame
- Cancer stage at time of diagnosis, treatment and mortality through study completion (likely 5 years)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site Exclusion Criteria: * Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as: * More than 100 cigarettes or 75g tobacco in their lifetime * Those who have received a prescription for nicotine replacement therapy * For prospective participants, those who cannot consent will be excluded
References
Publications (0)
Data not yet available