Clinical trial · Observational
Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell Carcinoma
NCT06575322CI-TRIAL-00080280recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn about the Effects of neoadjuvant therapy with carboplatin, paclitaxel combined with anti-PD-1 drugs on pain, anxiety and depression in patients with operable head and neck squamous cell carcinoma: a prospective cohort study
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Anti-PD-1 Drugs | Drug | — | UNRESOLVED |
| Carboplatin（ neoadjuvant） | Drug | — | UNRESOLVED |
| Paclitaxel （neoadjuvant） | Drug | Paclitaxel | ALIAS |
| Surgical resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Neoadjuvant therapy+ Surgery group( Group A)
- description
- The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), untreated, and planned to undergo surgical treatment + combined chemotherapy and immunotherapy.
- interventionNames
- Drug: Carboplatin（ neoadjuvant）
- Drug: Paclitaxel （neoadjuvant）
- Drug: Anti-PD-1 Drugs
- Procedure: Surgical resection
- label
- Direct surgery group (Group B)
- description
- The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), untreated, and planned to undergo surgery.
- interventionNames
- Procedure: Surgical resection
Primary outcomes (2)
- measure
- Brief Pain Inventory (Short Form)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: \- 1: Clinical diagnosis of head and neck squamous cell carcinoma (stage I-IVA), without prior treatment, and planning to undergo either surgical treatment alone or surgical treatment combined with chemotherapy and immunotherapy. 2: Ability to speak Chinese and possess basic reading and writing skills. Exclusion Criteria: * 1: Presence of mental illnesses such as dementia or delirium. 2: Active use of narcotic drugs, including consuming alcohol more than 4 times per day or more than 4 times per week. 3: Patients who alter their treatment plan during the course of treatment. 4: Current or prior use of antidepressants.
References
Publications (0)
Data not yet available
No reference posted for this study.