Clinical trial · Observational
Earlier Detection and Optimization of Treatment and Prognosis for Patients With Early-onset Colorectal Cancer
Striving for Earlier Detection and Optimization of Treatment and Prognosis for Patients With Early-onset Colorectal Cancer (EOCRC); BIO-EOCRC Study
NCT06568679CI-TRIAL-00093091BIO-EOCRCrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study aims to collect high quality clinical data on lifestyle and patient biomaterials prior to start or during / after treatment of early-onset colorectal cancer (EOCRC) and to inform on treatment and survival outcomes of EOCRC patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Early-onset Colorectal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No intervention; observational | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Exploratory data analysis through a multiomics approach describing tumor biology and pathogenesis of patients with EOCRC
- timeFrame
- Change from baseline throughout follow-up of 10 years
- description
- Associations between exposome (lifestyle factors and microbiome composition), genomics and transcriptomics and EOCRC will be determined by multivariate analysis. Multivariate tests will be applied to account for the complexity of the data and the multitude of variables involved, this will include multiple regression analysis, logistic regression analysis, and analysis of variance (ANOVA). These tests will allow us to identify and quantify the correlation between the factors and better understand the underlying mechanisms of EOCRC.
Secondary outcomes (7)
- measure
- Second tumor
- timeFrame
- Change from baseline throughout follow-up of 10 years
- description
- Linkage to the Netherlands Cancer Registry (NCR) and nationwide National Pathology Database (PALGA) to asses second malignancies.
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with locoregional or metastatic colorectal cancer (CRC) * Histologically proven CRC * Age 18 - 49 years at time of first CRC diagnosis * Able to understand the informed consent form * Provide written informed consent. Exclusion Criteria: * Mentally incompetent patients based on the opinion of treating physician * Inability to understand the Dutch language
References
Publications (0)
Data not yet available
No reference posted for this study.