Clinical trial · Observational
Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors
NCT06566222CI-TRIAL-00080053unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this observational study is to understand the effect of different timing of chemoradiotherapy on overall survival in patients with stage II/III low- and medium-level rectal cancer with or without high-risk factors
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Radiotherapy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| chemoradiotherapy after surgery | Procedure | — | UNRESOLVED |
| High-risk Factors | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- NAT+High
- interventionNames
- Other: High-risk Factors
- label
- NAT+Low
- label
- PAT+High
- interventionNames
- Procedure: chemoradiotherapy after surgery
- Other: High-risk Factors
- label
- PAT+Low
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 2024
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. The patient is between 18 and 80 years old; 2. Adenocarcinoma confirmed by pathology; 3. Colonoscopy or imaging examination confirmed that the distance between the lower edge of the tumor and the anal margin is ≤10cm; 4. ECOG score ≤2 (4) Imaging diagnostic analysis was cT1-3NxM0; (for Phase II/III) (5) CT examination of the chest and abdomen and pelvis showed no evidence of metastasis (6) Patients undergoing chemoradiotherapy and surgery Exclusion Criteria: 1. History of malignant tumors in the past; 2. Diagnosis of simultaneous multiple primary colorectal cancer or other cancers; 3. History of chemotherapy or radiotherapy prior to this trial 4. Those with contraindications to laparoscopic surgery, such as severe cardiopulmonary insufficiency; 5. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc., requiring emergency surgery; 6. Pregnant or lactating women; 7. Evidence of distant metastases prior to surgery 8. T4b tumors were found to invade the uterus, vagina, bladder, seminal vesicles, prostate, bone, and pelvic plexus
References
Publications (0)
Data not yet available
No reference posted for this study.