Clinical trial · Interventional
Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators carried out a multi-center comparative study, involving hospitals including the Second Affiliated Hospital of Zhejiang University School of Medicine, Peking Union Medical College Hospital, West China Hospital, Wenzhou First Hospital, and Li Huili Hospital. This study aimed to compare the efficacy of medication and surgery for specific subtypes of microadenomas and clearly defined macroadenomas (Knosp grades 0-2), in order to determine which is more effective and which has fewer benefits, thereby enhancing the evidence base.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Tumor | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bromocriptin 2.5mg, 2-3 times a day | Drug | — | UNRESOLVED |
| Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Operation group
- description
- Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy
- interventionNames
- Procedure: Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy
- type
- ACTIVE_COMPARATOR
- label
- Drug group
- description
- Bromocriptin 2.5mg, 2-3 times a day
- interventionNames
- Drug: Bromocriptin 2.5mg, 2-3 times a day
Primary outcomes (2)
- measure
- pituitary hormone levels
- timeFrame
- At 1, 3, 6, 9 and 12 months postoperatively
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Prolactin level greater than three times the normal upper limit * MRI indicates Knosp Grade 0-2 pituitary adenoma Exclusion Criteria: * MRI indicates Knosp grade 3-4 pituitary adenoma * Taking antidepressants or other psychotropic drugs * Patients allergic to bromocriptine or cannot tolerate surgery * Women defined as surgical infertility (i.e. hysterectomy, bilateral salpingectomy, or bilateral oophorectomy), or amenorrhea for more than 2 years * Critical illness patients, such as those with progressive consciousness disorders, cerebral hernias, and other emergency situations
References
Publications (0)
Data not yet available