Clinical trial · Interventional
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder). Overall survival (OS: overall survival) after surgery crucially depends on the response to neoadjuvant chemotherapy. Current criteria for predicting histological response in preoperative imaging are not satisfactory. The working hypothesis is that it is possible to better differentiate the tissue response to conventional chemotherapies and anti-angiogenics through MRI elastography by quantifying the changes in tissue mechanical properties induced by systemic treatments. The objectives is to evaluate the mechanical properties obtained by elasto MRI according to the systemic treatments envisaged: conventional chemotherapy such as Folfox or combined with targeted therapy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer With Liver Metastases | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| an elastoMRI sequence | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- immediately resectable patients.
- description
- 10 immediately resectable patients receiving preoperative chemotherapy based on Folfox alone.
- interventionNames
- Other: an elastoMRI sequence
- type
- OTHER
- label
- potentially resectable patients
- description
- 30 potentially resectable patients (borderline) with two groups of patients representing the usual combinations of triplets: chemotherapy and targeted therapy: Folfox + bevacizumab (15 patients) and Folfox + Cetuximab (15 patients).
- interventionNames
- Other: an elastoMRI sequence
- type
- OTHER
- label
- unresectable patients
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients ≥18 years old, followed for colorectal cancer with hepatic metastases. The diagnosis of metastasis can be made: either by tumor biopsy or by the appearance during follow-up of colorectal cancer of at least one liver lesion with the characteristics of metastasis (fibrous tumor type imaging) * Patient with an indication to receive first-line chemotherapy for liver metastases, whether or not associated with targeted therapy * Patient with at least one hepatic metastasis greater than 2cm Exclusion Criteria: * Patients not affiliated with social security * Pregnant or breastfeeding women * Patients under guardianship, curatorship or safeguard of justice * Patients with a contraindication to MRI or to the injection of contrast agent in MRI. The classic contraindications for MRI are defined by the French Society of Radiology:http://www.sfrnet.org/sfr/professionnels/1-fiche-information-patients/irm/index.phtml * Lack of signed patient consent
References
Publications (0)
Data not yet available