Clinical trial · Interventional
A First-in-Human Study of EOS301984 as Monotherapy or Combination Therapy in Adult Participants With Advanced Solid Tumors
A First-in-Human Open-label, Phase I Dose Escalation and Expansion Cohort Study of EOS301984 as Monotherapy and in Combination With Other,Anticancer Treatments in Participants With Advanced Solid Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
APT-008 is an open-label, Phase I/Ib, dose escalation and expansion cohort study to evaluate the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and preliminary efficacy of EOS301984 as monotherapy and in combination with other anticancer therapies in participants with advanced solid tumors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Solid Tumors | Solid Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Anti-PD-1 monoclonal antibody | Drug | Anti-PD1 Monoclonal Antibody | ALIAS |
| EOS301984 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Part 1A dose escalation
- description
- EOS301984 dose escalation as monotherapy
- interventionNames
- Drug: EOS301984
- type
- EXPERIMENTAL
- label
- Part 1B dose escalation
- description
- EOS301984 in combination with other cancer therapies
- interventionNames
- Drug: EOS301984
- Drug: Anti-PD-1 monoclonal antibody
Primary outcomes (2)
- measure
- To characterize the safety and tolerability of EOS301984 alone and in combination with other anticancer agents in participants with advanced solid tumors
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
INCLUSION CRITERIA * Provide a signed written informed consent before any study-specific evaluation. * Be at least 18 years old on the day of signing informed consent. * Have a histologically confirmed advanced solid tumor for which no standard approved treatment is available, or are ineligible for, or did not tolerate standard approved treatment. * Have at least one tumor lesion measurable per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Have adequate organ and marrow function. * Agree to use adequate highly effective method of contraception during the study is mandatory, if Women of Childbearing Potential (WOCBP) or male. EXCLUSION CRITERIA * Have received prior systemic anticancer treatment including investigational agents within 4 weeks before the first dose of study treatment. * Have major surgery planned or have had a major surgery within 5 weeks before the first dose of the study treatment. * Have received prior radiotherapy within 2 weeks before the first dose of study treatment. * Have allergy to study treatment(s) or any of its components. * Have a history or current evidence of uncontrolled or significant cardiovascular disease. Unable to comply with the requirements of the study or who, in the opinion of the Investigator, should not participate in the study. * Pregnant or breastfeeding women.
References
Publications (0)
Data not yet available