Clinical trial · Interventional
Prehabilitation During Neoadjuvant Chemoradiotherapy for Rectal Cancer
Effect of Prehabilitation on Rectal Cancer Surgery Following Neoadjuvant Chemoradiotherapy: A Randomized Prospective Cohort Study
NCT06542354CI-TRIAL-00079573completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is determine whether a trimodel prehabilitation program (combined with physical exercise, nutrition supplement and mental support) during neoadjuvant chemoradiotherapy can help patients with rectal cancer to achieve better postoperative outcomes include perioperative complication rate, functional outcomes and quality of life.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mental support | Behavioral | — | UNRESOLVED |
| Nutrition supplement | Dietary Supplement | — | UNRESOLVED |
| Physical exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Prehabilitation
- description
- 6-week trimodel prehabilitation program consists of physical exercises, nutrition supplement and mental support for patients with rectal cancer during neoadjuvant chemotherapy before surgery. All patients will receive ERAS care pattern after surgery.
- interventionNames
- Behavioral: Physical exercise
- Dietary Supplement: Nutrition supplement
- Behavioral: Mental support
- type
- NO_INTERVENTION
- label
- Standard care
- description
- Patients receive no specific interventions mentioned above during their neoadjuvant chemoradiotherapy. All patients undergoing primary leision resection will receive postoperative ERAS care.
Primary outcomes (1)
- measure
- Functional outcome
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with rectal cancer undergoing/scheduled for neoadjuvant chemoradiotherapy * Fried Frailty score≥2 (intermediately frail or frail) * Written consent informed Exclusion Criteria: * Co-morbiditie contraindicating physical exercise or causing disturbances of conciousness (dementia, Parkinson Disease, previous stroke with paresis, taking carbidopa/levodopa, donepezil or antidepressants) * Emergent surgery * ASA grade IV-V * Pregnancy (absence confirmed by serum/urine β-HCG) or breast-feeding * Known drug abuse/ alcohol abuse
References
Publications (0)
Data not yet available
No reference posted for this study.