Clinical trial · Observational
Detection of G-quadruplex DNA Methylation in Cancer
Early Diagnosis Value of G-quadruplex DNA Methylation in Patients with Cancer
NCT06537063CI-TRIAL-00084419withdrawnClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The existing basic research and the latest literature reports do not support the proposed protocol, therefore, the project is withdrawn.
Summary
Brief summary (as posted)
This study aims to evaluate the early diagnosis value of G-quadruplex DNA methylation in patients with cancer.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cell-free DNA | — | UNRESOLVED | — |
| DNA G-quadruplex | — | UNRESOLVED | — |
| Methylation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| G4 DNAm test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Asymptomatic population
- description
- Asymptomatic medical examination population.
- interventionNames
- Other: G4 DNAm test
Primary outcomes (1)
- measure
- G-quadruplex DNAm score
- timeFrame
- 2024.04.30-2024.09.30
- description
- Detection of DNAm around G-quadruplex loci in cell-free DNA from blood.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 42 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy volunteers identified as asymptomatic during medical examination; * Age≥42 years old; * Voluntarily participate in this study and sign the informed consent. Exclusion Criteria: * History of malignancy or having achieved complete remission following tumor surgery; * Certain autoimmune diseases (e.g., systemic lupus erythematosus, Sjögren's syndrome, antiphospholipid syndrome, rheumatoid arthritis, Crohn's disease, IgA nephropathy, myasthenia gravis, dermatomyositis, immune thrombocytopenic purpura, etc.); * Pregnancy; * Acute trauma (including surgical procedures), sudden onset organ failure (e.g., resulting from a car accident, fulminant hepatic failure, acute pancreatitis, severe pneumonia due to influenza virus), or diagnosis of sepsis; * Previous receipt of allogeneic blood transfusion, transplant surgery, or allogeneic cell therapy; * Volunteers who cannot provide informed consent.
References
Publications (0)
Data not yet available
No reference posted for this study.