Clinical trial · Observational
Decompression of Odontogenic Cysts
The Effect of Decompression on Histologic Diagnoses of Cystic Jaw Lesions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings. The main question it aims to answer is: Does decompression of cystic jaw lesions alter the histologic diagnosis? A retrospective analysis was performed based on the comparison of initial and final histologic diagnoses of patients with an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cysts Dental | — | UNRESOLVED | — |
| Keratocysts of the Jaw | — | UNRESOLVED | — |
| Odontogenic Cysts | — | UNRESOLVED | — |
| Pathology | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Change in histologic diagnosis following decompression (yes/no)
- timeFrame
- A decompression period ranging between 2 and 15 months
- description
- A comparison will be made between the initial histologic diagnosis and post-decompression definitive histologic diagnosis of the cystic jaw lesions
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * To have an initial diagnosis of an odontogenic cystic jaw lesion confirmed with an incisional biopsy. * The patients must have undergone decompression and, enucleation or enucleation and peripheral ostectomy after decompression period. Exclusion Criteria: * Previously treated patients * The patients with missing information in medical and/or dental records * The patients who did not adhere to follow-up protocol
References
Publications (18)
- RESULTRajendra Santosh AB. Odontogenic Cysts. Dent Clin North Am. 2020 Jan;64(1):105-119. doi: 10.1016/j.cden.2019.08.002. Epub 2019 Oct 18. PMID 31735221
- RESULTWakolbinger R, Beck-Mannagetta J. Long-term results after treatment of extensive odontogenic cysts of the jaws: a review. Clin Oral Investig. 2016 Jan;20(1):15-22. doi: 10.1007/s00784-015-1552-y. Epub 2015 Aug 8. PMID 26250795
- RESULTOliveros-Lopez L, Fernandez-Olavarria A, Torres-Lagares D, Serrera-Figallo MA, Castillo-Oyague R, Segura-Egea JJ, Gutierrez-Perez JL. Reduction rate by decompression as a treatment of odontogenic cysts. Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e643-e650. doi: 10.4317/medoral.21916. PMID 28809378
- RESULTMohanty S, Dabas J, Verma A, Gupta S, Urs AB, Hemavathy S. Surgical management of the odontogenic keratocyst: A 20-year experience. Int J Oral Maxillofac Surg. 2021 Sep;50(9):1168-1176. doi: 10.1016/j.ijom.2021.02.015. Epub 2021 Mar 2. PMID 33663899
- RESULTAnavi Y, Gal G, Miron H, Calderon S, Allon DM. Decompression of odontogenic cystic lesions: clinical long-term study of 73 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):164-9. doi: 10.1016/j.tripleo.2010.09.069. Epub 2010 Dec 30. PMID 21194990
- RESULTPogrel MA, Jordan RC. Marsupialization as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg. 2004 Jun;62(6):651-5; discussion 655-6. doi: 10.1016/j.joms.2003.08.029. PMID 15170272
- RESULTSchlieve T, Miloro M, Kolokythas A. Does decompression of odontogenic cysts and cystlike lesions change the histologic diagnosis? J Oral Maxillofac Surg. 2014 Jun;72(6):1094-105. doi: 10.1016/j.joms.2013.12.028. Epub 2014 Jan 15. PMID 24576437