Clinical trial · Interventional
Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor Surgery
NCT06530706CI-TRIAL-00095225completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate whether esketamine can relieve anxiety in patients undergoing abdominal tumor surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anxiety State | — | UNRESOLVED | — |
| Esketamine | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Esketamine | Drug | — | UNRESOLVED |
| normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experiment group
- description
- Esketamine 0.2mg/kg was given slowly after intubation, and then 0.1mg/kg/h was pumped continuously until the end of the operation. Patients received sufentanil based patient-controlled intravenous analgesia (PCIA) within 72 hours postoperatively, with sufentanil combined with esketamine 1mg/kg in a PCIA device.
- interventionNames
- Drug: Esketamine
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- Same volume of normal saline was given slowly after intubation, and then pumped continuously until the end of the operation. Patients received sufentanil based patient-controlled intravenous analgesia (PCIA) within 72 hours postoperatively, without esketamine in the PCIA device.
- interventionNames
- Drug: normal saline
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing abdominal tumor surgery; * older than 18 years old and younger than 70 years old; * ASA grade I-III； * Hamilton anxiety scale ≥ 8. Exclusion Criteria: * Having serious mental illness before surgery or on antipsychotic medication in the two weeks before screening; * Severe organ function lesions such as heart failure (left ventricular ejection fraction \<30%), myocardial infarction, kidney failure (requiring kidney replacement therapy), liver function impairment (Child-Pugh grade C), etc. * Patients arranged to receive general anesthesia combined with epidural anesthesia patients; * Patients who cannot communicate, read or write due to visual, auditory, language or other reasons; * Patients allergic to ketamine; * Patients refused to use postoperative self-controlled intravenous analgesia pump; * Patients refused to participate in the study.
References
Publications (0)
Data not yet available
No reference posted for this study.