A Study of PD5K3 in Healthy Adult Volunteers

Inclusion Criteria:

1. Chinese healthy male or female subjects;
2. Aged 18 to 65 years (inclusive);
3. The body mass index (BMI) in the range 18.0\~28.0 kg/m\^2 (inclusive);
4. Voluntarily participate and sign the informed consent form;
5. Be able to complete the trial in accordance with the protocol.

Exclusion Criteria:

1. Suffering from any diseases of the circulatory system, digestive system, urinary system, respiratory system, nervous system, endocrine system, reproductive system, etc. or any other diseases that can interfere with the test results;
2. Abnormal results with clinically significance of comprehensive physical examination, vital signs, laboratory tests (blood routine, blood biochemistry, seven coagulation items, urine routine, myocardial enzymes), 12-lead electrocardiogram, chest X-ray (anteroposterior), abdominal B-ultrasound (liver, gallbladder, pancreas, spleen and kidney);
3. Allergic constitution, including allergic to asparaginase;
4. Used PEGylated drugs in the past;
5. Fasting blood glucose ≥ 6.1mmol/L;
6. Have difficulty in venous blood collection, have a history of needle phobia or blood phobia, or have a known severe bleeding tendency;
7. Positive urine test for drug abuse;
8. Positive breath test for alcohol;
9. Smoke excessively (average \> 5 cigarettes/day) within 3 months before screening or cannot stop using any tobacco products during the trial;
10. Drink excessively every day within 3 months before screening (male daily alcohol consumption exceeds 25g, such as 750 mL of beer, 250 mL of wine, or 75 mL of 38° liquor; female daily alcohol consumption exceeds 15g, such as 450 mL of beer, 150 mL of wine, or 50 mL of 38° liquor), or cannot abstain from alcohol during the trial;
11. Drink excessive amounts of tea, coffee or caffeinated beverages every day within 3 months before screening (more than 8 cups per day, 1 cup = 250 mL);
12. One or more positive tests for hepatitis B virus surface antigen, hepatitis C virus antibody, syphilis specific antibody, and human immunodeficiency virus antibody;
13. Female subjects are in lactation or have positive blood pregnancy test during the screening period or trial;
14. Undergone surgery within 3 months before screening or plan to undergo surgery during the trial;
15. Donated blood or lost more than 400 mL of blood within 3 months before screening (excluding menstrual bleeding);
16. Participated in any clinical trial as a subject within 3 months before screening;
17. Took any prescription drugs, over-the-counter drugs, health products, and any functional vitamins or Chinese herbal products within 28 days before administration;
18. The subject or his/her partner is unwilling to use one or more non-drug contraceptive measures (such as complete abstinence, condoms, contraceptive rings, ligation, etc.) for contraception during this trail or have a fertility plan within 6 months after the end of the study;
19. The investigator believes the subject would be unsuitable for participation in this clinical study.