Clinical trial · Interventional
Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development. The aims of this study are : * Assess the caries risk in childhood cancer survivors compared with a control group. * Assess the dental development defects risk in childhood cancer survivors compared with a control group.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chemotherapy Effect | — | UNRESOLVED | — |
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Dental Caries | — | UNRESOLVED | — |
| Malocclusion | — | UNRESOLVED | — |
| Tooth Defect | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Clinical and radiographic dental examination | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cancer survivor
- interventionNames
- Diagnostic Test: Clinical and radiographic dental examination
- type
- ACTIVE_COMPARATOR
- label
- Control
- interventionNames
- Diagnostic Test: Clinical and radiographic dental examination
Primary outcomes (1)
- measure
- Assessment of the caries experience by using the Decay Missing Filled Teeth score (DMFT)
- timeFrame
- Thoughout the entire study, approximately during 2 years
- description
- Assess the impact of the chemotherapy agents on the risk of ulterior caries development
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 36 Years
Show eligibility criteria text
Inclusion Criteria: * age below 10 at cancer diagnosis (for the CCS group). * Chemotherapy must have been used to treat the patient (For the CCS group). * The patient is 12 years old or older at the time of the follow-up appointment of the present study Exclusion Criteria: * A patient who was diagnosed and treated after 10 years old. * Patient below 12 years old at time of study recruitment * Patients with syndrome or diseases that involve teeth impairment\* * Pregnant patient * Refusal or inaptitude to undergo dental and radiographic examination
References
Publications (0)
Data not yet available