Clinical trial · Interventional
Exercise as Maintenance Therapy in Advanced Lung Cancer
NCT06513663CI-TRIAL-00109478terminatedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): trial stopped due to low accrual
Summary
Brief summary (as posted)
The purpose of this study is to examine how a multimodality (having or using a variety of methods to do something) exercise intervention may improve survival, function, and quality of life in participants with advanced lung cancer.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Metastatic Lung Cancer | Malignant Lung Neoplasm | CURATED_BROADER | 0.78 |
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise Intervention
- description
- Eligible and consented participants randomized to the exercise arm will work with an exercise trainer three times weekly for 12 weeks. Training sessions will be delivered virtually using HIPPA Complaint IU Health Zoom. These sessions will last 60 minutes and include cardiovascular exercise, resistance training, and balance or stretching exercise. The participants will be able to use any equipment they already have at home but will be provided a heart monitor and a set of resistance bands. All sessions will have a moderate-intensity training goal, defined as 40-80% of heart rate reserve (HRR). Cardiovascular exercise will include any at-home equipment available to the participants or follow a Tabata-style program. Resistance training will include a full body workout, emphasizing all major muscle groups. Trainers will progress or regress intensity levels based on the participant's rate of perceived exertion (RPE), heart rate, and individual response during each session.
- interventionNames
- Behavioral: Exercise Intervention
- type
- NO_INTERVENTION
- label
- Usual Care
- description
- Participants randomized to usual care arm will receive care per their treatment team. Usual care participants are encouraged to exercise but will not be provided components of the intervention. Participants in the usual care arm will be given usual care handouts at baseline.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age ≥ 18 years 2. Known diagnosis of locally advanced (stage III) or metastatic NSCLC 3. Patient is currently receiving maintenance immunotherapy for at least 1 month and planned for at least 3 additional months of therapy 1. Patients receiving maintenance therapy refers to patients with stable disease or partial response to therapy, including patients who have had a history of disease progression but are currently stable or responding to a different therapy 2. Patients previously receiving chemotherapy are eligible as long as at least one month has elapsed since completing chemotherapy. Those currently receiving chemotherapy are not eligible. 4. Patient is willing and able to participate in a supervised home-based exercise program as determined by the MOVE program a.Participants must have internet access and equipment to participate in virtual exercise 5. ECOG performance status of 0-2 Exclusion Criteria: 1. Already meeting exercise guidelines and participating in at least 150 minutes of moderate or vigorous exercise per IPAQ 2. Unable to participate in the supervised home-based exercise program as determined by the MOVE program 3. Medical co-morbidities that preclude patient from participating in supervised exercise, including but not limited to: * Advanced heart failure * Advanced respiratory disease requiring home oxygen use * Uncontrolled psychiatric disorders * History of fragility fracture
References
Publications (0)
Data not yet available
No reference posted for this study.