Clinical trial · Interventional
Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Prognostic Impact of a 3-week Multimodal Prehabilitation Program on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients. This study aimed to evaluate whether multimodal prehabilitation consisting of preoperative physical therapy, nutritional support, and cognitive exercises decreases postoperative complications and improves functional recovery in frail elderly patients undergoing gastric cancer surgery, in comparison to usual clinical care.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Elderly | — | UNRESOLVED | — |
| Frail | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Prehabilitation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 3-week multimodal prehabilitation program | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 3-week multimodal prehabilitation program+perioperative care guided by ERAS protocols
- description
- This program included four components: aerobic and resistance exercises, respiratory training, nutritional counseling with whey protein supplementation, and psychological adjustment.
- interventionNames
- Procedure: 3-week multimodal prehabilitation program
- type
- NO_INTERVENTION
- label
- perioperative care guided by ERAS protocols
- description
- Perioperative care of the control group was based on standardized ERAS recommendations that have been widely implemented to minimize heterogeneity in perioperative care. Typically, participants did not receive any preoperative interventions related to exercise, nutrition, or mental health.
Primary outcomes (2)
- measure
- postoperative complications
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients over the age of 65; 2. Patients with a Fried Frailty Index score of 2 or higher; 3. Patients who were scheduled for surgical resection of gastric adenocarcinoma; 4. Patients whose life expectancy was estimated by the surgeon to be greater than six months - Exclusion Criteria: Patients were excluded from the study if they: 1. were scheduled for neoadjuvant therapy; 2. had metastatic cancer; 3. were unable to swallow or participate in exercise and fitness assessments due to pre-existing conditions (e.g., orthopedic, neuromuscular, or cardiorespiratory diseases); 4. had low compliance, defined as executing less than 70% of the weekly plan; 5. had incomplete data or were lost to follow-up. -
References
Publications (1)
- DERIVEDChen J, Hong C, Chen R, Zhou M, Lin S. Prognostic impact of a 3-week multimodal prehabilitation program on frail elderly patients undergoing elective gastric cancer surgery: a randomized trial. BMC Gastroenterol. 2024 Nov 11;24(1):403. doi: 10.1186/s12876-024-03490-7. PMID 39528916