Clinical trial · Interventional
Danish Vulva Cancer Recurrence Study
The Value of Patient-reported Outcome Measure Assessment and Circulating Tumor-DNA to Detect Early Relapse During Surveillance in Women With Vulva Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The overall aim is to investigate different aspects of recurrence detection in women with vulva cancer (VC) to identify optimal treatment- and surveillance programs. DaVulvaRec is a Danish nationwide multicenter study with patient inclusion from Aarhus University Hospital and Rigshospitalet, Denmark. Applying a mixed method research design, the investigators will collect and analyze patient-reported outcome measures in combination with procedural data to evaluate symptomatology and map actions taken during the patient's pathway from primary disease to recurrence. Furthermore, the investigators aim to examine if circulating tumor-DNA (ctDNA) can be detected in liquid biopsies from VC patients. All patients will be followed for two years or until recurrence. Patient-reported outcome measures will be completed every four months during surveillance, and liquid biopsies will be collected prospectively for later analyses. Total number of patients to be included is 295 according to a power calculation. All patients in the clinical study will be included in the intervention group, while data on a historical control group will be obtained from The Danish Gynecological Cancer Database. Hence, the control group will consist of 1000 VC patients diagnosed between 2011-2022. Hypotheses: * All patients with VC will have specific tumor markers in the primary tumor that will be detectable in liquid biopsies as ctDNA at the time of diagnosis. * Measurement of ctDNA after primary treatment and during surveillance will allow detection of residual disease, improve allocation for adjuvant treatment, and will allow early detection of recurrent VC. * Proactive use of repeated PROM assessments in combination with procedural actions during surveillance will allow early detection of recurrent VC and early identification of late effects after treatment.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Circulating Tumor DNA | — | UNRESOLVED | — |
| PROM | — | UNRESOLVED | — |
| Survivorship | — | UNRESOLVED | — |
| Vulva Cancer | — | UNRESOLVED | — |
| Vulva Disease | — | UNRESOLVED | — |
| Vulva Neoplasm | Vulvar Neoplasm | ALIAS | 0.90 |
| Vulvar Cancer | Malignant Vulvar Neoplasm | CURATED_EXACT | 0.92 |
| Vulvar Diseases | — | UNRESOLVED | — |
| Vulvar Neoplasms | Vulvar Neoplasm | ONTOLOGY_EXACT |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Algorithmically determined telephone interview with a nurse | Other | — | UNRESOLVED |
| Collection of patient-reported outcomes | Other | — | UNRESOLVED |
| Measurement of circulating tumor-DNA | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- PROM assessment and ctDNA detection during surveillance
- description
- All participants (n=295) included in the prospective clinical study
- interventionNames
- Diagnostic Test: Measurement of circulating tumor-DNA
- Other: Collection of patient-reported outcomes
- Other: Algorithmically determined telephone interview with a nurse
- type
- NO_INTERVENTION
- label
- Standard surveillance
- description
- Historical controls (n=1,000) who will be identified by the Danish Gynecological Cancer Database
Primary outcomes (2)
- measure
- Recurrence-free survival
- timeFrame
- Two years
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Primary or recurrent biopsy-verified squamous cell carcinoma of the vulva * ≥ 18 years of age * Able to understand oral and written information in Danish Exclusion Criteria: * Active treatment for concurrent cancer and/or dissemination of concurrent cancer
References
Publications (0)
Data not yet available