Clinical trial · Observational
Chemotherapy Induced Neuropathy in Cancer Patients
Evaluation of Chemotherapy Induced Neuropathy in Solid Cancer Patients
NCT06491082CI-TRIAL-00078637CINunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this prospective study is to perform Nerve conduction test, Vitamin D, Vitamin B12 and NADPH oxidase 4(NOX4) expression to assess severity of chemotherapy induced Peripheral neuropathy (CIPN) in solid cancer (Head and Neck, Breast, Prostate) patients who planned for at least 4 cycle of chemotherapy in different nutrient status level and gene expression.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chemotherapy-induced Peripheral Neuropathy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cisplatin, Carboplatin, Paclitaxel, Docetaxel | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Baseline and after 4th cycle
- description
- Histopathologically diagnosed Solid Cancer Patients Planned for Platinum and Taxane based chemotherapy will be going for Neuropathy test- Nerve conduction test(NCV), vitamin D, B12 and Nox4 expression at Baseline and after 4th cycle of chemo
- interventionNames
- Drug: Cisplatin, Carboplatin, Paclitaxel, Docetaxel
Primary outcomes (5)
- measure
- Assessment of different type and severity of Neuropathy in Solid Cancer Patients Undergoing Chemotherapy using Total Neuropathy Score(TNS) and Nerve conduction velocity study
- timeFrame
- Baseline and after 4th cycle of chemotherapy ( 3weekly cycle) 84 days
- description
- Sensory symptoms, Motor Symptoms, Pin sensation, Vibration sensibility, Strength, Tendon reflexes will be recording using likert scale from 0 to 5 "0= None, 1= Limited to fingers or toes, 2= Extend to ankle or wrist, 3= Extend to knee or elbow, 4= Above knees/elbows".
- measure
- NOX4 Gene Expression in Blood of Solid Cancer Patients Undergoing Chemotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients receiving chemotherapy for solid cancer * Patient aged\>18years Exclusion Criteria: * Age ≤ 18 years * Pre-existing neuropathy * Patients diagnosed with Psychiatric illness * Patients with pre-existing peripheral neuropathy * Patients taking medication for neuropathy * Long standing diabetes (\>10 years) * Renal and Hepatic disease
References
Publications (0)
Data not yet available
No reference posted for this study.