Clinical trial · Interventional
High Versus Lower Intensity Surveillance Following Resection of Retroperitoneal Sarcoma
An International, Partially-randomised, Patient-preference Trial Within a Registry of High Versus Lower Intensity Radiological Surveillance Following Primary Resection of Retroperitoneal, Abdominal and Pelvic Soft Tissue Sarcoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The SARveillance trial is an efficient, pragmatic, multi-centre, international, stratified, partially-randomised, patient-preference trial within a registry of high versus lower intensity radiological surveillance following primary resection of retroperitoneal, abdominal and pelvic soft tissue sarcoma. The trial design is stratified by sarcoma tumour grade (high/intermediate grade and low grade).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sarcoma Retroperitoneal | Sarcoma | PROBABILISTIC | 0.70 |
| Sarcoma,Soft Tissue | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High-intensity radiological surveillance | Diagnostic Test | — | UNRESOLVED |
| Lower-intensity radiological surveillance | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- High-intensity radiological surveillance
- description
- High/intermediate grade histology: 3-4 monthly CT scan up to 2-years postoperatively, 6-monthly CT scan from 2-5 years postoperatively (schedule 1) Low grade histology: 6-monthly CT scan up to 2-years postoperatively, annual CT scan from 2-5 years postoperatively (schedule 2)
- interventionNames
- Diagnostic Test: High-intensity radiological surveillance
- type
- ACTIVE_COMPARATOR
- label
- Lower-intensity radiological surveillance
- description
- High intermediate grade histology: 6-monthly CT scan up to 2-years postoperatively, annual CT scan from 2-5 years postoperatively (schedule 2) Low grade histology: Annual CT scan up to 2-years postoperatively, 18 monthly CT scan from 2-5 years postoperatively (schedule 3)
- interventionNames
- Diagnostic Test: Lower-intensity radiological surveillance
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (greater than 18 years) * Primary resection * Histologically confirmed retroperitoneal, abdominal or pelvic soft tissue sarcoma * R0/R1 resection * Eligible whether or not the participant undergoes neoadjuvant treatment Exclusion Criteria: * Metastatic disease at time of randomisation * Recurrent, metastatic or residual disease identified on baseline CT imaging (3-4 months post primary resection) * Reoperation for recurrent soft tissue sarcoma * Re-resection following previous inadequate surgery * R2 resection * Patients receiving adjuvant therapy that will delay, interrupt or render radiological surveillance unpredictable * Uterine sarcomas, gastrointestinal stromal tumour (GIST), fibromatosis, epithelial tumours, multifocal disease, sarcomas of bony origin * Patient declined to consent to data sharing with RESAR (unless in a centre contributing via pre-planned IPDMA)
References
Publications (2)
- BACKGROUNDWhitaker J, Nessim C, Almond M, Ford SJ. Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma. Curr Oncol. 2023 Feb 26;30(3):2781-2791. doi: 10.3390/curroncol30030211. PMID 36975424
- BACKGROUNDBaia M, Ford SJ, Dumitra S, Sama L, Naumann DN, Spolverato G, Callegaro D. Follow-up of patients with retroperitoneal sarcoma. Eur J Surg Oncol. 2023 Jun;49(6):1125-1132. doi: 10.1016/j.ejso.2022.02.016. Epub 2022 Mar 4. PMID 35277304