Clinical trial · Interventional
Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis and Staging of Lung Malignancies
Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis of Suspected Lung Cancer & Staging of Concurrent Mediastinal Lymphadenopathy at Ain-Shams University Hospitals
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis. Fludeoxyglucose-18 (FDG) positron emission tomography (PET) combined with low dose contrast computed tomography (CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are two diagnostic modalities widely used in the field of staging \& diagnosis of lung malignancies, the former depends on image analysis while the later enables real-time sampling of lymph nodes under sonographic guidance with concurrent cytological examination. The present research aims to compare the diagnostic and staging accuracies of (EBUS-TBNA) versus FDG-PET /CT as two diagnostic modalities in patients with suspected lung malignancies. However as a secondary outcome this study aims at monitoring the possible complications arising post EBUS-TBNA procedure.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Malignancies | Lung Neoplasm | PROBABILISTIC | 0.70 |
| Mediastinal Lymphadenopathy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endo bronchial ultrasound transbronchial needle aspiration(EBUS-TBNA) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- FDG PET and EBUS TBNA arm
- description
- It is a single arm in which all patients undergo FDG PET and EBUS-TBNA
- interventionNames
- Diagnostic Test: Endo bronchial ultrasound transbronchial needle aspiration(EBUS-TBNA)
Primary outcomes (2)
- measure
- Comparing the diagnostic accuracies of both EBUS TBNA and FDG-PET /CT
- timeFrame
- 2 years
- description
- Comparing the diagnostic yield of both modalies as they are considered primary main diagnostic and staging modalities for lung malignancies
- measure
- Comparing the staging accuracies of both convex probe EBUS-TBNA versus FDG - PET/CT
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients 18 years old or more. * Patients presented with centrally located suspiciously malignant lung masses with or without lymphadenopathy. * patients with mediastinal lymphadenopathy only as evident by contrast - enhanced CT scan of the chest. * patients with peripheral lung malignancy and mediastinal lymphadenopathy who were referred for MLN staging were also recruited to the research Exclusion Criteria: * All patients who were who were unfit for bronchoscopy as per international guidelines for practice. * Cases are diagnosed with stage IV (metastatic) lung cancer. * Patients with histopathological diagnosis other than malignancy (as Sarcoidosis, Tuberculosis). * patients unfit for FDG-PET G-PET/CT examination (uncontrolled Hyperglycemia, renal impairment). * Patients who refused to participate to the study.
References
Publications (2)
- BACKGROUNDSehgal IS, Agarwal R, Dhooria S, Prasad KT, Aggarwal AN. Role of EBUS TBNA in Staging of Lung Cancer: A Clinician's Perspective. J Cytol. 2019 Jan-Mar;36(1):61-64. doi: 10.4103/JOC.JOC_172_18. PMID 30745743
- BACKGROUNDKuo CH, Chen HC, Chung FT, Lo YL, Lee KY, Wang CW, Kuo WH, Yen TC, Kuo HP. Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: a study in a tuberculosis-endemic country. PLoS One. 2011 Feb 25;6(2):e16877. doi: 10.1371/journal.pone.0016877. PMID 21364919