Correlation of Portal and Peripheral Venous ctDNA in Pancreatic Adenocarcinoma

Inclusion Criteria:

* Age ≥ 18 years
* Patient with operable pancreatic adenocarcinoma (resectable or boderline with or without neoadjuvant therapy) with histological evidence or indirect diagnostic criteria (CA 19-9 Significant (≥ 200 U/ml), pancreatic hypodense lesion without differential diagnosis)
* Biological criteria: Neutrophils \> 1,500 cmm, platelet count \> 100,000 cmm, creatinine clearance (Cockroft and Gault equation) \> 60 ml/min, hemoglobin \> 10 g/dl.
* ECOG performance status 0 or 1
* Patient has read and understood the information letter and signed the non-opposition/consent form.
* For an adult unable to give consent: Representative of the adult who has read and understood the information letter and signed the consent form

Exclusion Criteria:

* Other active cancer or haematological malignancy
* Uncontrolled congestive heart failure - untreated angina pectoris; recent myocardial infarction (within the last year) - uncontrolled hypertension (SBP \> 160 mm or DBP \> 100 mm, despite optimal drug therapy), long QT.
* Uncontrolled major infections, chronic infectious diseases, immunodeficiency syndromes
* Premalignant hematological disorders, e.g. myelodysplastic syndrome
* Severe hepatic impairment
* Patients not registered with social security
* Pregnant, parturient or breast-feeding woman (a pregnancy test will be carried out unless there is a history of hysterectomy, tubal ligation or menopause)
* Person deprived of liberty by an administrative or judicial decision, or person placed under court protection, sub-guardianship or guardianship.
* History of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol, or to prevent him/her from giving informed consent.
* Treatment contraindicated for venous sampling