Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients

Inclusion Criteria:

* Cohort 1 - Non-operable patients

  * Patients aged at least 18 years old and ≤ 70 years old; male or female.
  * AND available biopsy
  * AND Karnofsky index ≥ 50% at Screening
* Cohort 2 - Elderly patients

  * Patients aged \> 70 years old; male or female
  * AND Balducci score I or II. For patients classified in Balducci II, only light Balducci II will be included, as defined by a Charlson score \<4 and a score of autonomy IADL = 4. In the oncogeriatric evaluation, symptoms related to brain cancer disease have not to be considered for this criterion.
  * Karnofsky score (KPS) of ≥ 70% at Screening
  * Regardless resection
  * MRI at maximum 48h00 after surgery if partial, subtotal or macroscopically complete or supra-total resection
* For both cohorts

  * Histologically confirmed diagnosis of glioblastoma (GBM) (2016 OMS classification) (Louis et al., 2016).
  * Contrast enhancing disease on MRI within 14 days prior to screening.
  * Within 2 weeks of baseline visit, hematologic and renal functions as specified: Absolute neutrophil count ≥ 1500/mm3, platelets ≥ 100,000/mm3, Hgb ≥ 9.0g/dL, creatinine ≤ 1.7mg/dl, total bilirubin ≤ 1.5mg/dL, blood urea nitrogen (BUN) within 2 times the upper limit of normal, transaminases ≤ 4 times above the upper limits of the institutional norm.
  * Sexually active patients must use an acceptable method of contraception while receiving doses of study medication.
  * Females of childbearing potential must have a negative serum or urine pregnancy test at screening and have additional pregnancy tests during study.

Exclusion Criteria:

• For both cohorts

* Any previous radiotherapy (RT) of the brain whatever the interval between previous brain RT and diagnoses of GBM)
* Any previous treatment of the GBM (except surgery) such as chemotherapy (including Gliadel wafer or gliasite application), immunotherapy, therapy with a biologic agent, hormonal therapy or Carmustine implant for brain tumors or immunotherapy, including vaccination (whatever the interval between previous treatment and diagnoses of GBM). Glucocorticoid therapy is allowed.
* Previous digestive disease with mis-absorption such as Crohn disease or chronic colitis
* Ongoing diarrhea grade ≥ 2 in the NCI CTCAE V5.0 (whatever the cause)
* Inclusion in another trial in the 30 previous days
* Patient who cannot undergo MRI
* Pregnant or lactating woman.
* Serious concurrent infection or medical illness that would jeopardize the ability of the patient to receive study treatment with reasonable safety.
* Patients with previous cancer (\< 5 years) except basocellular skin tumors and in situ cervix tumor
* Patient has a known hypersensitivity to crocetins, L-TC or any of its excipients.
* Contraindication of temozolomide as described in the Summary of product characteristics.
* Patient who cannot understand French language.
* Patient without French National Health insurance
* Patient who cannot be reliable for follow-up
* Patient under law protection