Clinical trial · Interventional
Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer
Multispectral Optoacoustic Tomography for the Detection of Extranodal Extension and Radiation Induced Fibrosis in Head and Neck Squamous Cell Cancer
NCT06477003CI-TRIAL-00122446OUSCCMOTORXsuspendedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Administrative reasons.
Summary
Brief summary (as posted)
The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in patients with metastatic head and neck squamous cell carcinomas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Multispectral Optoacoustic Tomography | Device | — | UNRESOLVED |
| Temperature Measurement | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm 1 - surgery patients
- description
- 70 patients with clinically confirmed metastatic head and neck squamous cell carcinomas (N+ HNSCC) planned for definitive surgery will be imaged using the MSOT device prior to surgery. Skin temperature will be measured prior to and after MSOT imaging to assess for safety.
- interventionNames
- Device: Multispectral Optoacoustic Tomography
- Procedure: Temperature Measurement
- type
- EXPERIMENTAL
- label
- Arm 2 - radiotherapy patients
- description
- 30 patients with clinically confirmed metastatic head and neck squamous cell carcinomas (N+ HNSCC) planned for definitive radiotherapy (RT) (+/- chemo) will be imaged using the MSOT device before, during, and after radiotherapy. 15 patients will be treated with photon RT and 15 patients will be treated with proton therapy. Skin temperature will be measured prior to and after MSOT imaging to assess for safety.
- interventionNames
- Device: Multispectral Optoacoustic Tomography
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Clinically confirmed node positive head and neck squamous cell cancer * Written informed consent signed and dated by the patient prior to the performance of the MSOT * At least 18 years-of-age at the time of signature of the informed consent form (ICF) * Patients planned for curative intent therapy * Patient available for the study duration * Patients of childbearing potential must have a negative pregnancy test prior to the study entry. * Patients of childbearing potential must use an effective form of contraceptive as per the protocol. Exclusion Criteria: * History of previous head and neck radiotherapy * Intent of treatment palliative * Women who are pregnant * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety of efficacy assessment of the investigational regimen should be included. * Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol and/or follow-up procedures outlined in the protocol.
References
Publications (0)
Data not yet available
No reference posted for this study.