Clinical trial · Interventional
Investigation of Standard Excision Surgical Margins Using Two Photon Fluorescence Microscopy
NCT06473103CI-TRIAL-00087301recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during standard local excision.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinoma | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Two photon fluorescence microscopy imaging | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- TPFM imaging of surgical margins
- description
- Excised tissue will be imaged with TPFM to determine the distance from tumor to nearest inked margin.
- interventionNames
- Device: Two photon fluorescence microscopy imaging
Primary outcomes (1)
- measure
- Quantitative agreement between clear margin distance on TPFM and conventional paraffin embedded histology
- timeFrame
- Upon receipt of postoperative pathology slides, typically 2-4 weeks post surgery
- description
- The distance from the furthest extent of the tumor to the nearest surgical margin will be measured on both TPFM and conventional paraffin histology and the numerical difference calculated.
Secondary outcomes (1)
- measure
- Overall agreement on margin status
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Undergoing treatment for basal cell carcinoma without Mohs surgery at the performance site * Able to read and understand consent form Exclusion Criteria: * None
References
Publications (1)
- BACKGROUNDChing-Roa VD, Huang CZ, Ibrahim SF, Smoller BR, Giacomelli MG. Real-time Analysis of Skin Biopsy Specimens With 2-Photon Fluorescence Microscopy. JAMA Dermatol. 2022 Oct 1;158(10):1175-1182. doi: 10.1001/jamadermatol.2022.3628. PMID 36069886