Clinical trial · Interventional
Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery
Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery (PICCS-1)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (PMID:37373843). More broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (PMID: 35231076). In spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in Singapore. We therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Diet, Healthy | — | UNRESOLVED | — |
| Flatus | — | UNRESOLVED | — |
| Ileus Postoperative | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nestle Boost Optimum | Dietary Supplement | — | UNRESOLVED |
| Nestle Isocal | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- Arm 1
- description
- Control arm with no nutritional supplementation
- type
- ACTIVE_COMPARATOR
- label
- Arm 2
- description
- Control arm with nutritional supplementation but without probiotics
- interventionNames
- Dietary Supplement: Nestle Isocal
- type
- EXPERIMENTAL
- label
- Arm 3
- description
- Nutritional supplementation with probiotics
- interventionNames
- Dietary Supplement: Nestle Boost Optimum
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: 1. undergoing elective colorectal cancer surgery in which an oncologic resection is planned 2. age between 21 and 99 years at the time of consent 3. willing to consider oral nutritional supplementation 4. on an early recovery after surgery (ERAS) pathway 5. able to provide informed consent Exclusion Criteria: 1. patients with known contraindications to probiotic use 2. patients undergoing emergency surgery 3. taking any other form of probiotics 4. taking oral antibiotics within 7 days of commencement of study 5. vulnerable patients including pregnant patients, inmates, and those who are cognitively impaired and therefore are not able to provide informed consent.
References
Publications (1)
- DERIVEDChan DKH, Siew BE, Lau J, Koh J, Lee MX, Ang C, Pang NQ, Tan KK. Time to return of bowel function following perioperative probiotics in colorectal cancer surgery (PICCS-1): study protocol for a randomized controlled trial. Trials. 2025 Feb 19;26(1):60. doi: 10.1186/s13063-025-08773-2. PMID 39972354