Clinical trial · Interventional
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Squamous cell carcinoma (SCC) could be a very aggressive cancer and has a bad prognosis if not detected early and thus is associated with high mortality. The development of simple and reliable biomarkers for the early detection of SCC is one of the solutions to better diagnose, treat these tumors, evaluate and monitor treatments, and hence reduce mortality. In a previous work, the investigators demonstrated the ability of Proton Magnetic resonance spectroscopy (1H-MRS) to non-invasively assess spectroscopic and metabolic profiles of tongue tissue in healthy subjects. In the present work, the investigators challenge the use of in-vivo 1H-MRS as a potential method for non-invasive metabolic monitoring of patients with squamous cell carcinoma of the tongue undergoing therapy. Thus the main objective is to study the spectroscopic and metabolic differences, e.g. including variation in the metabolite TMA-Cho (trimethylamine-choline), of tongue tissue between healthy subjects and in patients with squamous cell carcinoma of the tongue, before and after surgery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Proton Magnetic Resonance Spectroscopy | — | UNRESOLVED | — |
| Soft Tissue Tumors of the Tongue | — | UNRESOLVED | — |
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Transcriptomics | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI and MRS acquisitions | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- patients
- description
- Patients with a lingual tumor measuring less than 15 mm in long axis
- interventionNames
- Other: MRI and MRS acquisitions
- type
- ACTIVE_COMPARATOR
- label
- healthy volunteers
- description
- Subjects without a history of cancer of the upper aerodigestive tract Subjects without contraindication to MRI Subjects over 18 years old Subjects who have provided free and informed written consent Subjects benefiting from a social security system
- interventionNames
- Other: MRI and MRS acquisitions
Primary outcomes (2)
- measure
- variation in the metabolite TMA-Cho (trimethylamine-choline), between healthy subjects and patients before surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Patients: * Patients from the maxillofacial surgery department of the Amiens-Picardie University Hospital treated for histologically confirmed squamous cell carcinoma of the tongue * Patients who have not yet been treated, either surgically or by neoadjuvant treatment * Patients with a tumor of minimum dimensions of 15 mm in long axis * Patients without contraindication to MRI * Patients over 18 years old * Patients who have provided free and informed written consent * Patients benefiting from a social security system Healthy volunteers: * Subjects without a history of cancer of the upper aerodigestive tract * Subjects without contraindication to MRI * Subjects over 18 years old * Subjects who have provided free and informed written consent * Subjects benefiting from a social security system Exclusion Criteria: * Patients: * Patients with a lingual tumor measuring less than 15 mm in long axis Patients and healthy volunteers: * Patients with other histological types of cancer, or other locations * Subjects with a contraindication to MRI * Subjects under 18 years old * Pregnant or breastfeeding women * Persons under guardianship, curators, protection of justice or deprived of liberty
References
Publications (0)
Data not yet available