Clinical trial · Observational
Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter
Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Using Extracellular Volume Measured in Delay Phase
NCT06441357CI-TRIAL-00077687unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The core purpose of this study is to investigate whether the extracellular volume (ECV) fraction measured in delay phase by dual energy computed tomography (DECT) can distinguish precancerous lesions from early-stage lung adenocarcinomas, which could assist clinical decision making for surgery operation indication and strategy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenocarcinoma of Lung | Lung Adenocarcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Patients with preinvasive lung adenocarcinomas
- description
- preinvasive lung adenocarcinomas include atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA)
- label
- Patients with invasive lung adenocarcinomas
- description
- invasive adenocarcinoma(IAC)
Primary outcomes (1)
- measure
- Acquire DECT parameters in patients with pulmonary nodules.
- timeFrame
- 2 years
- description
- Including iodine concentration (IC) in delay phase, normalized IC (NIC), effective atomic number (Zeff), and CT attenuation values of nodules from virtual monochromatic images (VMIs) (energy range from 40 to 150 keV, 10keV as interval).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients older than 18 years old with pulmonary nodules (diameter≤3 cm). * pathologically confirmed as lung adenocarcinoma. * without history of other malignancies. * accurate hematocrit within 1 week before contrast enhanced dual energy CT examination. Exclusion Criteria: * with a history of allergy to iodine contrast agents and other reasons who are unable to complete the examination. * without histopathology of invasion stage, such as AAH, AIS, MIA and IAC. * history of chemotherapy, radiotherapy, or other anti-tumor therapy before contrast enhanced dual energy CT. * poor image quality. * contrast enhanced dual energy CT scans ≥ 4 weeks before surgery.
References
Publications (0)
Data not yet available
No reference posted for this study.