Clinical trial · Observational
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
SURVIVORS Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors. Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. . Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity. CONTROLS Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hodgkin Lymphoma, Adult | Adult Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Near Infrared Spectroscopy (NIRS) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- SURVIVOR
- description
- A survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. and Control: Voluntarily taking part in this study because you are a relative, friend or employee of St. Jude Children's Research Hospital.
- interventionNames
- Device: Near Infrared Spectroscopy (NIRS)
Primary outcomes (1)
- measure
- Near-Infrared Spectroscopy (NIRS)
- timeFrame
- Baseline
- description
- a non-invasive imaging technology that is used to measure regional or global cerebral tissue oxygenation and cerebral blood flow (CBF) during exercise. NIRS takes advantage of the fact that oxygenated blood and de-oxygenated blood absorb light differently. By measuring the reflected light from blood, the concentration of both oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (HbdO2) using the modified Beer-Lambert Law can be calculated.
Secondary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: HL Survivors * Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH. * \<21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy. * SJLIFE or ACT/SJLIFE participants * English language proficiency. Community Controls * SJLIFE control. * ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors. Exclusion Criteria: HL Survivors * History of cranial or total-body irradiation therapy. * History of intrathecal or high dose intravenous antimetabolite therapy. * History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.
References
Publications (0)
Data not yet available