Clinical trial · Interventional
Resistance Exercise and Creatine in Colorectal Cancer
The Feasibility and Acceptability of Resistance Training and Creatine Supplementation to Promote Physical Function in Sarcopenic Colorectal Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Low skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients. This condition arises from a combination of factors such as aging, inactivity, treatment side effects, malnutrition, tumor burden, and inflammation. Given this complexity, singular interventions may not be sufficient to address low muscle mass in this group. Creatine monohydrate, a compound vital for energy during exercise, has been extensively researched and proven safe and effective across various demographics, including older adults and clinical populations. Studies show that creatine enhances benefits from resistance training, indicating potential to counter muscle mass and function decline post-cancer treatment. This study aims to assess the feasibilty of combining creatine supplementation with resistance training versus resistance training alone in colorectal cancer survivors treated with chemotherapy. A randomized controlled pilot trial will compare a 10-week program of resistance exercise plus creatine (EXSUPP) with resistance exercise alone (EXPLA), each with 20 participants.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Resistance Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise + Creatine
- description
- 3 days a week of resistance exercise for 10-weeks + 5g day of creatine monohydrate supplementation
- interventionNames
- Behavioral: Resistance Exercise
- type
- PLACEBO_COMPARATOR
- label
- Exercise + Placebo
- description
- 3 days a week of resistance exercise for 10-weeks + 5g day of placebo (dextrose supplementation
- interventionNames
- Behavioral: Resistance Exercise
Primary outcomes (4)
- measure
- Recruitment
- timeFrame
- 10-weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Individuals ≥12 months post treatment with chemotherapy for colorectal cancer * \>18 years Exclusion Criteria: 1. are receiving active treatment for their cancer; 2. had a musculoskeletal, cardiovascular, neurological, or psychological condition that precluded participation in RET; 3. had been participating in structured RET two or more times per week for the past 6 months 4. are currently taking supplements containing creatine for 4 weeks prior to the start of the RCT, or 5. are receiving medications that might alter body composition (metformin, corticosteroids etc.).
References
Publications (1)
- DERIVEDFairman CM, Brooks AM, Candow DG, Jackson KE, Bottone G, Scott B, Anderson KS, Hirsch KR, Cardaci TD, VanderVeen BN, Blake CE, Zhang T, Zhang J, Murphy EA. Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer. PLoS One. 2026 Jul 15;21(7):e0353630. doi: 10.1371/journal.pone.0353630. eCollection 2026. PMID 42455839