Clinical trial · Observational
Atezolizumab and Bevacizumab Combination Recommended in a Multidisciplinary Consultation Meeting in Caen for Hepatocellular Carcinoma (ABCHCaen)
Study of the Atezolizumab and Bevacizumab Combination Recommended in a Multidisciplinary Consultation Meeting in Caen for Hepatocellular Carcinoma.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In France primary liver cancers (PLC) is the fourth leading cause of cancer-related death in men, and the seventh in women. The number of new cases per year is predicted to increase by 26.5% between 2020 and 2040. Hepatocellular carcinoma (HCC) account for 75% to 85% of PLC. It occurs mostly on cirrhotic livers. Diagnosis remains late in almost half of the patients so that a palliatif treatment is frequent. In advanced cases sorafenib has been so far the first line systemic therapy since 2008. In 2020 a phase 3 study has demonstrated a better overall survival in patients treated with bevacizumab associated with atezolizumab as compared to sorafenib (19.2 months vs 13.4 months) and a better quality of life. Noweday immunotherapy is recommended in first line in cases of ECOG 0/1 unresectable HCC without liver insufficiency. However the study included 70% of viral liver diseases while HCC are related to alcohol and steatohepatitis in 50% of cases in France. Moreover patients with high risk of oesophageal variceal bleeding were excluded. Recent real life data published worldwide confirm the bitherapy efficacy and good tolerability. By contrast french data are scarces, with a single serie of 43 patients in which median overall survival was estimated to 12 months. Our main aim is to determine the overall survival of HCC patients treated with atezolizumab and bevacizumab in Caen from april 2021.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atezolizumab and Bevacizumab in Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 3 years
- description
- Overall survival in patients with hepatocellular carcinoma
Secondary outcomes (3)
- measure
- progression-free survival
- timeFrame
- 3 years
- description
- progression-free survival in patients with hepatocellular carcinoma
- measure
- predictors of response to treatment
- timeFrame
- 3 years
- description
- predictors of response to Atézolizumab and Bevacizumab
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age superior or equal to 18 years * patients with advanced hepatocellular carcinoma * treatment validated in multidisciplinary consultation meeting Exclusion Criteria: * patients with another kind of liver cancer
References
Publications (1)
- DERIVEDMetivier C, Campani C, Allaire M, Morello R, Mouri S, Spitzer E, Bouattour M, Hollande C, Sidali S, Nault JC, Ganne-Carrie N, Nahon P, Amaddeo G, Regnault H, Vigneron P, Peron JM, Sadek L, Cussac C, Lequoy M, Ozenne V, Galais MP, Perignon C, Lebedel L, Habireche M, Commin A, Dao T, Costentin C, Baron A, Hourmand IO. Atezolizumab-bevacizumab in very elderly with hepatocellular carcinoma: Age alone is not a limiting factor except in ALBI grade 3. JHEP Rep. 2026 Jun;8(6):101827. doi: 10.1016/j.jhepr.2026.101827. Epub 2026 Mar 17. PMID 41856249