Clinical trial · Observational
Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers
Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Environmental Exposure | — | UNRESOLVED | — |
| SDH Gene Mutation | — | UNRESOLVED | — |
| SDH-Related Familial Paraganglioma | Hereditary Paraganglioma | ALIAS | 0.90 |
| SDHx-Related Syndromes | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Cases
- description
- Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor
- label
- Controls
- description
- Controls : SDHx mutation carriers with no SDHx-related tumor
Primary outcomes (1)
- measure
- Impact of SDHi exposure in paraganglioma occurence
- timeFrame
- 36 months
- description
- Association between exposures and tumor occurrence measure with Odd ratio
Secondary outcomes (2)
- measure
- Spatial distribution of cases
- timeFrame
- 48 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor * Controls: SDHx mutation carriers with no SDHx-related tumor Exclusion Criteria: * Incapacity to exercise free and informed consent for the study * Patient under tutorship or guardianship or legal safeguard
References
Publications (0)
Data not yet available