Clinical trial · Interventional
Predicting Esophageal Cancer Borders Using PET-Imaging
Predicting Esophageal Cancer Borders Using PET-Imaging PEGASUS
NCT06408116CI-TRIAL-00105160PEGASUSrecruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study examines the diagnostic precision of endosonography, mpMRI and PET/CT in defining tumor boundaries and tumor spread before and after neoadjuvant therapy and definitive surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophagus Cancer, Stage I | — | UNRESOLVED | — |
| Esophagus Cancer, Stage II | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chemotherapy | Drug | Chemotherapy | ALIAS |
| photon | Radiation | — | UNRESOLVED |
| surgical therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- Group 1, Surgery
- description
- cT1-2 N0, all histologies: primary surgical therapy
- interventionNames
- Procedure: surgical therapy
- type
- OTHER
- label
- Group 2, Chemotherapy and surgery
- description
- cT3-4 and/or N+, adenocarcinomas: neoadjuvant chemotherapy, surgical therapy
- interventionNames
- Procedure: surgical therapy
- Drug: Chemotherapy
- type
- OTHER
- label
- Group 3, chemotherapy, radiotherapy and surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed adenocarcinoma or squamous cell carcinoma of the esophagus, including AEG I and AEG II tumors in the primary situation * Planned surgical treatment of esophageal carcinoma * Possible staging advantage through FAPI PET/CT diagnostics * Patient information and written consent -\> KI 60% or ECOG 0/1 (at least: self-sufficiency) * Age ≥ 18 years Exclusion Criteria: * Previous radiation therapy in the tumor region * Previous tumor disease with \< 5 years of remission * Surgical therapy is not functionally or technically possible * Distant metastasis * Patient is not capable of giving consent * Concurrent participation in another clinical trial that could affect the results of this trial or the other trial * Illnesses that do not allow the person concerned to assess the nature and scope as well as possible consequences of the clinical study * pregnant or breastfeeding women * Signs that the person taking part is unlikely to comply with the therapy (e.g. unwillingness to cooperate)
References
Publications (0)
Data not yet available
No reference posted for this study.