Clinical trial · Interventional
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy：a 2× 2 Factorial Randomized Clinical Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure, favoring bleeding and cerebral cerebral hypoperfusion. The ideal analgesia for neurosurgery requires complete pain relief, eliminates the side effects of opioid drugs and no influence for neurological function. Previous studies have proposed a multimodal analgesic strategy, combining analgesics and local anaesthesia, it is expected to achieve the above benefits.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
| Supratentorial Brain Tumor | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Local analgesic techniques | Other | — | UNRESOLVED |
| no Local analgesic techniques | Other | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Local analgesic techniques + dexmedetomidine group
- description
- The patients in this group will be received scalp nerve block before surgery with 0.67 % liposomal bupivacaine. The patients also will be given dexmedetomidine intravenously at a rate of 0.4 μg/kg/h from skin incision until the beginning of dura mater closure, and will be adjusted to 0.05 μg/kg/h for 48 hours after surgery.
- interventionNames
- Drug: Dexmedetomidine
- Other: Local analgesic techniques
- type
- EXPERIMENTAL
- label
- Local analgesic techniques and placebo dexmedetomidine group
- description
- The patients in this group will be received scalp nerve block before surgery with 0.67 % liposomal bupivacaine. For dexmedetomidine placebo group, normal saline will be infused at the same rate as dexmedetomidine during surgery and for 48 hours after surgery.
- interventionNames
- Drug: Normal saline
- Other: Local analgesic techniques
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Aged from 18 to 65 years * American Society of Anesthesiologists physical status I to III * Scheduled to undergo elective supratentorial tumor resection Exclusion Criteria: * Incision-area skin infection * A history of previous craniotomy * Allergy to study medications * A history of preoperative change in consciousness or cognitive function * Severe hepatic or renal dysfunction * Severe bradycardia (heart rate\<40 beats/min) * Sick sinus syndrome or second- to-third degree atrioventricular block
References
Publications (0)
Data not yet available