Clinical trial · Interventional
Topical Application of PRF Before Radiation Therapy
Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer
NCT06406530CI-TRIAL-00088454PRFrecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket. Secondary aim is to monitore the effect on the pain perception.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| PRF | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Natural Healing | Procedure | — | UNRESOLVED |
| PRF | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- PRF site (test site)
- description
- The participants become at least two teeth removed, one site is applied with PRF (test site) while the other is left for natural healing by forming a blood clot (control site). Operator and Investigator as well as the Patient are blinded to to the site of application.
- interventionNames
- Procedure: PRF
- type
- ACTIVE_COMPARATOR
- label
- Blood clot (control site)
- description
- The participants become at least two teeth removed, one site is applied with PRF (test site) while the other is left for natural healing by forming a blood clot (control site). Operator and Investigator as well as the Patient are blinded to to the site of application.
- interventionNames
- Procedure: Natural Healing
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Head and neck cancer with planed radiation therapy * Bilateral tooth extraction * Similar tooth size * Atraumatic tooth extractions without flap surgery * Patients age above 18y of age Exclusion Criteria: * Prior radiation therapy in the head and neck area * Prior and current therapy with bisphosphonates or equivalent modern biologics * Patients during pregnancy or breastfeeding
References
Publications (0)
Data not yet available
No reference posted for this study.