Clinical trial · Observational
Observational Study on Invasive Fungal Infection Incidence in Ph-neg Acute Lymphoblastic Leukemia Patients
Prospective Observational Study on the Incidence of Invasive Fungal Infections in Patients With Ph-negative Acute Lymphoblastic Leukemia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Primary objective To document the occurrence of fungal infections during the early stages of chemotherapy (from onset to TP2, i.e., week 16) in adult Ph-neg ALL patients Secondary objectives * To document the occurrence of IFI in relation to antifungal prophylaxis adopted * To document the occurrence of IFI in relation to the age of the patients * Document the occurrence of IFI in relation to the duration of neutropenia * Document the occurrence of IFI in relation to the type of steroid treatment adopted (dexamethasone yes vs no) * Document any delays in the initiation of consolidation chemotherapy in LLA patients with IFI * Document the outcome of patients with ALL with IFI Study design The study is prospective and observational, multicenter, real-life study involving 26 centers afferent to the SEIFEM group. All Ph-neg ALL patients aged 18 years or older treated with intensive chemotherapy starting from 01.06.22 for the duration of 18 months (+12 months follow-up) will be enrolled. The diagnosis of IFI will be defined according to EORTC 2019 criteria. Clinical information will be collected in paper CRFs, compiled anonymously. The incidence of IFI and pulmonary aspergillosis during induction chemotherapy will be related to the following variables: * Age * Sex * Type of AF prophylaxis performed * LLA risk classification according to ESMO 2016 criteria * Dose of dexamethasone administered * Duration of neutropenia * Hematologic and molecular response
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Incidence of IFI during the early stages of chemotherapy (from onset to TP2, i.e., week 16) in Ph-neg ALL patients
- timeFrame
- 16 weeks
- description
- Incidence of IFI during the early stages of chemotherapy (from onset to TP2, i.e., week 16) in Ph-neg ALL patients
Secondary outcomes (6)
- measure
- - Incidence of IFI in Ph-neg ALL patients during induction in relation to antifungal prophylaxis adopted
- timeFrame
- 16 weeks
- description
- \- Incidence of IFI in Ph-neg ALL patients during induction in relation to antifungal prophylaxis adopted
- measure
- - Incidence of IFI in patients with Ph-neg ALL during induction in relation to age
- timeFrame
- 16 weeks
- description
- \- Incidence of IFI in patients with Ph-neg ALL during induction in relation to age
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with B Ph-neg or T ALL at onset * Age \> 18 yr at the time of the study * Signature informed consent Exclusion Criteria: * Patients with Ph-pos ALL * Patients with relapsing ALL * Patients with B/T lymphoblastic lymphoma
References
Publications (0)
Data not yet available