Clinical trial · Interventional
Interventions for the Management of Perineal Cancer Pain
Cooled Radiofrequency in Comparison to Either Conventional Radiofrequency Thermocoagulation or Neurolytic Block of Ganglion Impar in the Management of Perineal Cancer Pain
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pain associated with neoplasms may be of somatic, visceral, or neuropathic origin.Visceral pain or pain that is mediated by the sympathetic fibers in the perineal area associated with malignancy in the pelvis may be effectively treated with neurolysis of impar ganglion.In recent years, radiofrequency lesioning of the ganglion Impar has evolved as a novel non pharmacological technique for the management of patients suffering from intractable perineal pain.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Rectum | — | UNRESOLVED | — |
| Cancer Vagina | — | UNRESOLVED | — |
| Cancer Vulva | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| conventional radiofrequency | Device | — | UNRESOLVED |
| cooled radiofrequency , | Device | — | UNRESOLVED |
| neurolysis of ganglion | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Conventional radiofrequency
- description
- In this group we will use conventional radiofrequency thermocoagulation in the management of perineal cancer pain
- interventionNames
- Device: conventional radiofrequency
- type
- ACTIVE_COMPARATOR
- label
- Cooled radiofrequency
- description
- In this group we will use cooled radiofrequency in the management of perineal cancer pain
- interventionNames
- Device: cooled radiofrequency ,
- type
- ACTIVE_COMPARATOR
- label
- Neurolytic block of Ganglion
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Cancer patients aged from 20-70 years old, with lower third cancer rectum, caner vulva, cancer vagina and cancer perineum. 2. The intensity of perineal pain on VAS score ≥ 5. 3. Unsatisfactory treatment with tramadol (400 mg daily) , Pregabalin (150 mg daily) or presence of side effects of tramadol as headache, dizziness, constipation, rash, sweating, dry mouth. 4. Included participants should show adequate response to diagnostic ganglion impar block , i.e. reduction of VAS pain score \> 50% at least for 2 hours. Exclusion Criteria: 1. Infection of the skin at or near site of needle puncture. 2. Coagulopathy or prolonged bleeding time. 3. Drug hypersensitivity or allergy to the studied drugs. 4. Central or peripheral neuropathy . 5. Significant organ dysfunction as respiratory , liver or renal failure. 6. Any psychiatric illness that would interfere with the perception and the assessment of pain. 7. Vertebral anomalies. \-
References
Publications (0)
Data not yet available